Date:   2/13/2013 11:40:43 AM ( 11 y ago)
Hits:   39,029
URL:   https://www.curezone.org/forums/fm.asp?i=2035441

It wise to first consider if you are high histamine or low (under-methylator or low) before embarking on Inositol use.
Anxiety and Depression are fairly common in both states so it's really important to first know if you are high or low as low histamine folk DONT want inositol.

I now know why i reacted so badly to SAMe - lifelong symptoms pointed to high histamine/low methylation - so i embarked on raising methlylation and took a one time dose of 400g of SAMe. 3 hours later i told my boyfriend to remove all sharp objects from the house due to extreme agitation/depression/hopelessness and strong suicidal tendencies. Never felt anything like it. (im not on any medications at all to contradict the SAMe).

As a comparison my BF took the same dose on another day and felt no change whatsoever.

So it's more than likely i'm low histamine, high methylator.

I'm going to get tested as it's impossible at times to go by symptoms alone - even if those symptoms are severe - they could be due to something else.
I truly believed through weeks of research after crashing i was extreme hyper adrenal and thyroid, super fast metaboliser etc - going by my many extreme symptoms - only to be shocked to learn i'm extreme hypo-adrenal, hypo-thyroid and super slow oxidiser! (being skinny and still losing weight does NOT fit the profile of HYPO and slow oxidiser)

If you KNOW you're methylation status and histamine levels then inositol can help hugely. If you're not sure - just buy a little bit and try it on a 'free day' in case of reactions. Just because something is naturally occuring in the body doesn't mean it's 'safe' to take - especially if in an imbalanced state. I'd hate anyone to go through what i did with SAM-e.

Sherpa did the right thing with starting slow and low :-)




HIGH HISTAMINE EXCELLENT PAGE:

http://digitalnaturopath.com/cond/C446553.html


Vitamin Inositol Hexaniacinate
Inositol is especially helpful for undermethylated persons (for example most persons with OCD), but can cause negative side effects in those who are overmethylated. Since Inositol is one of the primary second messengers in neurotransmission, it's surprising it isn't more commonly used. It's especially useful in reducing anxiety and enhancing sleep.

To enhance sleep for a 160 lb person, we usually recommend 650mg tablets, 1-3 as needed for sleep. Persons who have difficulty falling asleep should take it 30-60 minutes before sleep. Persons whose main problem is waking up in the middle of the night should take it at bedtime.

We've often given as much as 3-4 grams/day to undermethylated persons who respond beautifully to Inositol, and these persons take it morning, noon, and evening.

I once gave an invited presentation at a symposium at an APS annual meeting... in which data on megadoses (15-30 g) of Inositol were reported by another speaker. The volume of Inositol used seemed extreme to me, and would present daunting compliance problems. I believe such huge doses of Inositol are unnecessary, if methionine, calcium, B-6, and other nutrients to combat undermethylation are used. However, massive doses of Inositol might be needed if one tries to combat OCD with Inositol alone.

Regardless of the form of inositol, its use should be started as a trial, with close monitoring of the patient. We've found that persons who achieve improved sleep after inositol are excellent candidates for taking it throughout the day also. I recommend you be alert for adverse side effects, especially with persons with severe anxiety or panic symptoms. [Willam Walsh, Ph.D., past senior scientist, Pfeiffer Treatment Center http://www.hriptc.org]



LOW HISTAMINE EXCELLENT RESOURCE:

http://digitalnaturopath.com/cond/C376401.html


" Inositol
Be alert for adverse side effects, should a low histamine (overmethylated) person with severe anxiety or panic symptoms be given inositol."

 

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