Lauricidin Monolaurin - Antibacterial, Antiviral, Antifungal at Antibiotic Resistant Bacteria

· Start with 1 scoop per day, divided into 4 doses over the day. Do for a couple days, and increase up to 3 scoops a day. Can be used as a preventive at this dose. For severe illness, increase to as many as 6 scoops per day. For skin infections, mix up into a cream and apply 3 or more times per day. See directions below for mixing a cream for Topical Application.

· Use blue scoop to dose Lauricidin. Put Lauricidin pellets in hand and then throw into mouth. Wash down with water or juice. Do not take with hot water, coffee, tea or other hot drink (the Lauricidin will dissolve in mouth in the hot liquid and cause an unpleasant taste).

· Take Lauricidin® in small amounts until you reach your level for optimal dosing level. Judge what dose you need to control or prevent a chronic or recurring infection, or susceptibility.

· Start with a few pellets for a few days, and slowly increase your dose up to 1-3 blue scoops per day, which is a commonly effective dosage. Reduce the dosage if you experience dieoff symptoms, or any other symptoms of aggravation.

· Your optimal daily dose may be anywhere from a few pellets per day to 1-3 blue scoops/day.

· When faced with stress or "coming down with something," increase the level during these times

· Do not take too much, too soon, in order to avoid a die-off (Herxheimer) reaction.

· Lauricidin® is a concentrated mini-pellet (30 mg per pellet) of sni (3)-monolaurin. Monolaurin as a class of direct food additives considered GRAS (Generally Regarded As Safe) by the US FDA. Lauricidin® is nontoxic and does not interact with most drugs or supplements.

· Because Lauricidin® is bioactive the exact amount that you need for optimal health depends on your diet and genetic make up.

· Children (3-10 years old): Do not chew pellets. To be taken with meals. The mini-pellets can be placed in the mouth and swallowed with water or juice. Do not take with hot liquids. Try placing the pellets (whole or powdered) into applesauce, pudding, peanut butter, etc.

· Very Young Children: it is best to start with 1-3 pellets/day for a several days before gradually increasing the dose.

· The usual initial level of Lauricidin® is increased gradually to twice/thrice daily for a week or two. The level can be further increased thereafter.

· Adults: Take with or after meals. The mini-pellets can be placed in the mouth and swallowed with water or juice. Do not take with hot liquids. Do not chew or take as a powder.

· The recommended initial level of Lauricidin® is 0.75 gram (1/4 blue scoop) or less two or three times daily for a week before increasing the amount.

· The level can be then increased to 1.5 grams (1/2 blue scoop) one, two or three times daily thereafter.

· A maintenance level can be 3.0 grams (one blue scoop) two or three times a day. In stubborn cases this may be increased. The length of time for taking the supplement is an individual response, and should to be taken on a continuing basis – much like vitamins.

· Put 1 tsp of pellets in 2 ounces of water in a heat resistant bowl (such as a soup bowl). Put in the microwave for 1 minute. The pellets will dissolve, and the water will be clear. Let the water cool, and stir occasionally (every 5-10 minutes). The water will form a white creamy paste that can be applied on athlete’s foot, jock itch, or skin fungus. It can be used in the mouth for thrush, but it is too concentrated in this form, dilute it down to a dilution that is tolerable for your taste buds, gargle, and spit. It could likewise be used as a douche for a yeast infection, but make sure the concentration is low enough so as to not irritate these delicate tissues.

· Lauricidin® is a nontoxic nutritional lipid. Lauricidin® may, however, increase the die off of microorganisms and result in a "Herxheimer Reaction," which can simulate the symptoms of flu, or create an acne-like breakout, or feel like allergic symptoms, etc. If these symptoms happen should reduce the dosage level or even stop for a few days before taking lower levels and then going higher. Present information on Lauricidin® suggests that it does not interfere with drug metabolism or other supplements. If taken together with other supplements, Lauricidin may increase their absorption.

· The antiviral, antibacterial, and antiprotozoal properties of lauric acid and monolaurin have been recognized for nearly four decades by only a small number of researchers. The original work by Kabara, has resulted in 50 or more research papers and numerous U.S. and foreign patents. In his seminal 1960 patent, Kabara documented the adverse effect of certain fatty acids (FAs) (e.g., medium-chain-saturates) and their derivatives (e.g., monoglycerides (MGs) on various microorganisms. While nontoxic and approved as a food additive by the FDA, monolaurin adversely affects bacteria, yeast, fungi, and enveloped viruses.Kabara found that the properties that determine the anti-infective action of lipids are related to their structure: e.g., free fatty acids & monoglycerides. The monoglycerides are active; diglycerides and triglycerides are inactive. Of the saturated fatty acids, lauric acid has greater antiviral activity than caprylic acid (C-8), capric acid (C-10), or myristic acid (C-14).

· Fatty acids and monoglycerides produce their killing/inactivating effect by perturbing the plasma membrane lipid bilayer. The antiviral action attributed to monolaurin is that of fluidizing the lipids and phospholipids in the envelope of the virus, causing the disintegration of the microbial membrane. This may not be the only mechanism since recent studies indicate that one anti-microbial effect in bacteria is related to monolaurin's interference with signal transduction/toxin formation (Projan et al 1994). Another antimicrobial effect in viruses is due to lauric acid's interference with virus assembly and viral maturation (Hornung et al 1994). The third mode of action may be on the immune system itself (Witcher et al, 1993).

· Hierholzer and Kabara (1982) initially reported recognition of the antiviral aspects of the antimicrobial activity of the monoglyceride of lauric acid (monolaurin). They showed virucidal effects of monolaurin on enveloped RNA and DNA viruses. This work was done at the Center for Disease Control of the U.S. Public Health Service. These studies were concluded with selected virus prototypes or recognized representative strains of enveloped human viruses. All these viruses have a lipid membrane. The presence of a lipid membrane on viruses makes them especially vulnerable to lauric acid and its derivative monolaurin. The initial findings have been confirmed by many other studies.

· Research has shown that enveloped viruses are inactivated in both human and bovine milk by added fatty acids and monoglycerides (Isaacs et al 1991). Others (Isaacs et al 1986, 1990, 1991, 1992; Thormar et al 1987) have confirmed Kabara's original statements concerning structure-function relationships.

· Some of the viruses inactivated by these lipids are the measles virus, herpes simplex virus (HSV-1 and -2), herpes family members (HIV, hepatitis C, vesicular, stomatitis virus (VSV), visna virus, and cytomegalovirus (CMV). Many of the pathogenic organisms reportedly inactivated by these antimicrobial lipids are those known to be responsible for opportunistic infections in HIV-positive individuals. For example, concurrent infection with cytomegalovirus is recognized as a serious complication for HIV positive individuals (Macallan et al 1993).

· Thus, it would appear to be important to investigate the practical aspects and the potential benefit of an adjunct nutritional support regimen for microbe-infected individuals, which will utilize dietary fats such as monolaurin. Until now, no one in the mainstream nutrition community seems to have recognized the added potential of antimicrobial lipids in the treatment of infected patients. These antimicrobial fatty acids and their derivatives are essentially nontoxic to man. According to the published research, lauric acid is one of the best "inactivating" fatty acids, and its monoglyceride is even more effective than the fatty acid alone (Kabara 1978, Sands et al 1978, Fletcher et al 1985, Kabara 1985).

· It should be emphasized that lauric acid cannot be taken orally because it is severely irritating. The lipid-coated (envelope) viruses, bacteria and other microorganisms are dependent on host lipids for their lipid constituents. The variability of fatty acids in the foods of individuals as well as the variability from de novo synthesis accounts for the variability of fatty acids in their membranes.

· Monolaurin has little adverse effect on desirable gut bacteria, and a strong effect on the potentially pathogenic microorganisms. For example, Isaacs et al (1991) reported no inactivation of the common Esherichia coli or Salmonella enteritidis by monolaurin, but major inactivation of Hemophilus influenza, Staphylococcus edpidermis and Group B gram-positive streptococcus.

· The potentially pathogenic bacteria inactivated by monolaurin include Listeria monocytogenes, Staphylococcus aureus, Streptococcus agalactiae, Groups A, streptococci- gram-positive organisms, and some gram-negative organisms (Vibrio parahaemolyticus and Helicobacter pylori).

· Decreased growth of Staphylococcus aureus and decreased production of toxic shock syndrome toxin-I was shown with 150-mg monolaurin per liter (Holland et al 1994). Monolaurin was 5000 times more inhibitory against Listeria monocytogenes than ethanol (Oh & Marshall 1993). In vitro medium-chain monoglycerides and lauric acid rapidly inactivate Helicobacter pylori, and there appears to be very little development of resistance of the organism to the bactericidal effects (Petschow et al 1996) of these natural antimicrobials.

· A number of fungi, yeast, and protozoa are also inactivated or killed by monolaurin. The fungi include several species of ringworm (Isaacs et al 1991). The yeast reported to be affected is Candida albicans (Isaacs et al 1991). The protozoan parasite Giardia lamblia is killed by monoglycerides from hydrolyzed human milk (Hemell et al 1986, Reiner et al 1986, Crouch et al 1991, Isaacs et al 1991).

· Chlamydia trachomatis is inactivated (Bergsson et al 1998), and hydrogels containing monocaprin/monolaunin are potent in vitro inactivators of sexually transmitted viruses such as HSV-2 and HIV-1 and bacteria such as Neisserian gonorrhea (Thormar 1999).

Lauricidin® Information

· Many Health Professionals suggest incorporating Lauricidin® into an overall strategy of lifestyle modification, dietary change, and food supplementation in better managing health problems.

· Many people have reported through the years increased energy and improved sense of wellbeing after Lauricidin® usage.

· Since Lauricidin® is nontoxic, the dosage can be gradually increased if needed for a particularly difficult infective condition. Each individual needs to determine the level that is suitable for his needs. One size does not fit all. It is recommended that you start with a low level and increase the level each week until you have a noticeable positive change.

· Please keep in mind that Lauricidin®, like vitamins, may not have an instant effect on your health. Although results have been seen in weeks, Lauricidin® should be taken 3-6 months before seeing optimum results. The length of time for taking the supplement is an individual response. Since even drugs DO NOT cure viral problems, the supplement needs to be taken on a continuing basis for restoring health and the ability to self-heal.

· One jar will normally last 4-6 weeks for an adult. The shelf life under ordinary conditions is more than three years. When kept at room temperature, samples kept in the laboratory over a period of 10 years have been shown to be stable.

· Lauricidin® was developed from Prof. Dr. Jon J. Kabara’s research, and other studies which have been ongoing since 1966. Lauricidin® (monolaurin) has been clinically tested and continues to be used by clinicians, health professionals and their patients.

· Lauricidin® is the purest monolaurin commercially attainable and is without any fillers or allergens unlike other preparations which may have 300 mg/capsule, plus inosine 7.5 mg, calcium-phosphate 106 mg, and inert ingredients dicalcium-phosphate, cellulose-powder and silicon-dioxide. To produce Lauricidin without fillers, additives or preservatives, Lauricidin® comes only in mini-pellet form.

· Lauricidin® can be easily powdered by using an ordinary kitchen grinder used for grinding nuts, coffee, etc. Grinding may be done for those having a hard time swallowing pills. The taste of the powder may be disguised (and difficulty of swallowing may be ameliorated) by placing the pellets (whole or powdered) into applesauce, pudding, peanut butter etc.

· Lauricidin contains as its active ingredient a molecule found in Mothers milk, Saw Palmetto and other natural products.

· Lauricidin is classified as a USFDA GRAS (Generally Regarded As Safe) food additive.

· Lauricidin may help restore normal flora, and inhibit/kill dysbiotic organisms, which may in turn help immune and bowel function, and result in an improved sense of well being.

· Shown in laboratories to inactivate bacteria, viruses and fungi/yeast.

· Does not destroy the body's friendly bacteria or form resistant organisms.

· Can be taken with most other medications

· Lauricidin® (monolaurin) is included on the GRAS (Generally Recognized As Safe) list. It is a molecule or natural origin, extracted commercially from coconuts, and found in breast milk. This is where the active monoglyceride of lauric acid (Monolaurin) is found. When an infant is born, it is totally dependent on food factors in the mother’s milk for immune protection. In analyzing the composition of human breast milk, medical researchers found lauric acid monoglycerides in high concentrations, which is what led them to study Monolaurin as an antiviral agent. Monolaurin (Lauricidin®) is also found in Saw Palmetto, Bitter Melon, and as a minor lipid component in some coconut oil; only recently has it been isolated and purified to mini-pellet form. It is unusual to find chemicals that are toxic to lower forms of life (bacteria, fungi, and viruses) but non-toxic to man.