Very few researchers have been interested in Trimethylaminuria, and very few papers published, especially over the last few years, since the genetic coding of FMO3 was discovered and then interest waned.

Probably 2 with the most interest would be Dr John Cashman in San Diego (HBRI) and The Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, led by Professor Yamazaki. The Japanese professor keeps a website on TMAU and seems to keep an interest in the subject.

In 2007, the 2 Dr's colluded to follow 5 cases of females who had compromised FMO3 function to varying degrees, and test their urine over 120 days to follow the result pattern, particularly to see how menstruation affected FMO3 function. Interestingly, only 2 of the cases are regarded as being 'TMAU' positive. The other 3 are regarded as normal (not having 2 mutant copies of FMO3), and yet all of them had lowered FMO3 function during menstruation.

Case A would be regarded as a 'true' textbook TMAU case, 2 mutant copies, and over the 120 days her FMO3 function was indeed very low over the whole period (under 50%), especially during menstruation.

Case B was homozygous for 1 common 'polymorphism', which are regarded as far less serious 'mutants' than real mutant DNA copies. Her FMO3 function was generally around 90% except during menstruation when it could dip to almost 0%

Case C was heterozygous for 2 common polymorphisms, and her FMO3 function was normal except around menses when it could reduce to around 60% function.

Case D & Case E were homozygous for wild FMO3, and also had normal function, but with a decrease in function to around 60-80% function around menses.

The conclusion seems to be that any female harboring 2 copies of any type of FMO3 enzyme known to not be 'perfect', whether 2 mutant copies, 2 polymorphism copies, or 2 wild types, may be prone to decreased FMO3 function around menstruation. It would be interesting to see how a female with one mutant copy would get on, or to a lesser extent, a female with one copy of a polymorphism or a wild type, to see if they were also at risk.

Looking at the TMA levels alone (not the TMA-oxide levels), the numbers aren't given, but it looks as if case A was always above 10.5 mmol, which is generally around the level accepted where TMA smells may become an issue. Case A seems to always be above 10.5, whereas the other 4 only seem to be above 10 around menstruation. It would be interesting to know why the TMA levels rise in the case of B,C,D and E. It is as if FMO3 plays some role in containing the bacteria causing TMA

I hate that time of the month i smell really bad just before that time of the month it starts during ovaltion and my body feels really warm on the inside like i have fever and i use to heal just 3 days now it's 6 days  i also know it has to do with our hormones and tma dont mix