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Re: niacin and high histamine by omo ..... Hypoglycemia Forum

Date:   10/24/2012 5:51:22 PM ( 12 y ago)
Hits:   7,264
URL:   https://www.curezone.org/forums/fm.asp?i=1999860

I don't know what an under methylator is, or any kind of methylator.


Methylation is one of our bodies' critical processes, responsible for activating enzymes, hormones, and detoxification processes. Most folk (perhaps 60%?) methylate just fine. Some don't methylate enough, and fewer still methylate too much.

Here are some symptoms (source):


UNDER METHYLATORS

Depression
High salivary flow
High tear flow
Never dry eyes
Good tolerance of cold
Poor tolerance of heat
Unexplained nausea
Hyperactivity
Frequent colds and flu
Phobias
Highly motivated
Hard driving personality
Poor pain tolerance
Joint pain
Joint swelling
Joint stiffness
Excess perspiration
Addictive tendencies
bipolar disorder
OCD
Schizophrenia
Insomnia
Muscle pains
Abundant or excess saliva in mouth
Obsessive compulsive
Slenderness
Do worse on b12 and folates (4)
Shopping/gambling disorders
Oppositional –defiant
Seasonal depression
Inhalant allergies
Frequent headaches,
Perfectionism
Competitiveness
Asthma
Vasomotor rhinitis
Allergic skin disorders
Pruritis
Excess stomach acid
Fatigue
High libido
Sparse body hair
Elevated absolute basophils
Extreme internal anxiety despite outwardly calm
Delusion thinking rather than hallucinations
Respond well to SAM-e, methionine, avoid folic acid (1)
Anorexia/bulimia
Low serotonin
Low dopamine
Low norepinephrine
Psychosis
Prone to hives
High motivation



OVER METHYLATORS

Elevated serotonin
Elevated dopamine
Elevated norepinephrine
High religiosity
High artistic/musical ability
Self injury
Auditory hallucinations
Absence of seasonal inhalant allergies
Frequent dry eyes
Multitude of chemical sensitivities
Multitude of food sensitivities
High anxiety evident to all
Low libido
Obsessions but not compulsions
Paranoia
Auditory hallucinations
Underachievement as child
Heavy body hair
Hyperactivity
Nervous legs
Grandiosity
Respond well to b12 but avoid SAM-e, inositol, methionine TMG and DMG (1)
Treatment revolves around folic acid, niacin, B12, and a high protein diet. (2)
Depression
Despair
Panic attacks
Upper body pain
Head pain
Nervous
Low salivary
Low tears
High pain tolerance
Low motivation
“space cadet”
Learning disabilities
Intolerance to SSRI drugs
Low perspiration


1 http://www.dr-bob.org/babble/20030525/msgs/229704.html

2 http://www.favoritedr.com/anxiety.html

3 http://www.digitalnaturopath.com/cond/C446553.html

4 http://www.latitudes.org/forums/index.php?showtopic=837



I have been researching both niacin and niacinamide and to me it seems they are pretty harmless. Over 3 g some folk say they can cause liver damage, especially if you have liver problems, but even that seems iffy and not at all well researched and other people say there is no problem for the liver.


Normally they're pretty harmless, yes. But make sure to pay attention to this:
Niacin’s safety record is equally impressive. However, a brief foray into the use of very-slow-release niacin preparations in the 1980s taught us an important lesson: niacin is very safe, if the liver is exposed to it for only a few hours at a time. Niacin is, after all, just vitamin B3. However, 24-hour, day-after-day exposure to niacin over an extended period can be toxic to the liver. Thus, the very-slow-release niacin preparations that yielded sustained, high blood levels of niacin caused liver toxicity in 10-20% of people who used these preparations in the 1980s. Unfortunately, this learning experience left some physicians fearful of recommending niacin to their patients. For this reason, very-slow-release niacin should be avoided.


And also note that niacin releases histamines, so if you have a lot pent up, you could be in for a histamine avalanche. Also, niacin uses up methyl groups when its deactivated. This is okay if you have enough methylation going on, but if you're deficient, this will make it worse.
 

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