Date:   3/15/2012 10:42:34 AM ( 12 y ago)
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URL:   https://www.curezone.org/forums/fm.asp?i=1918561

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Well, this is certainly synchronistic. After putting up the above post last night, a new research article comes out today implicating intestinal flora imbalances with Diabetes, Type I - http://www.nature.com/icb/journal/v90/n3/abs/icb2011115a.html?WT.ec_id=ICB-20...


As I've stated many times before, most autoimmune diseases are believed to originate in the gut. This study definitely demonstrates this. Although the researchers believe that they are making a new discovery, previous studies as outlined in my post above, provide the mechanisms by which this can happen.

From the study posted here -

"Dietary interventions, alterations in the intestinal microbiota and exposure to enteric pathogens, regulate the development of autoimmune diabetes in animal models. It has been demonstrated that these modulations affect the gut barrier mechanisms and intestinal immunity. Because the pancreas and the gut belong to the same intestinal immune system, the link between autoimmune diabetes and the gut is not unexpected.

Increased gut permeability, intestinal inflammation with impaired regulatory mechanisms and dysregulated oral tolerance have been observed in children with type 1 diabetes. The factors that contribute to these intestinal alterations are not known, but interest is focused on the microbial stimuli and function of innate immunity. It is likely that our microbial environment does not support the healthy maturation of the gut and tolerance in the gut, and this leads to the increasing type 1 diabetes as well as other immune-mediated diseases regulated by intestinal immune system. Thus, the interventions, aiming to prevent or treat type 1 diabetes in humans, should be targeting the gut immune system."

 

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