Date:   8/17/2011 7:36:21 AM ( 13 y ago)
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URL:   https://www.curezone.org/forums/fm.asp?i=1847506

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this is a Russian study that Cutler heavily relied upon in order to come up with his protocol

I was lucky to find a translation of it on a Yahoo autism chelation group. The translation is not perfect, but you can still tell what they are saying

the spacing is kind of screwed up but this is the best I can do. Go to the link for a better formatting

Basically they had several groups of rats. Two of the groups were constantly being poisoned purposefully by mercury vapor. Of those groups one was treated with ALA, the other was not

results show that the group that was treated with ALA had a much higher mercury excretion in both the urine and feces. Although there was a higher rate of excretion in the feces that in the urine

if you scroll all the way down to the end where they have conclusions, one of the conclusions is that ALA does two things.

1) binds to and removes mercury from the body

2) protects the body from the harmful effects of mercury

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http://health.groups.yahoo.com/group/Autism-Mercury/message/22067



GE Leskova (Kiev)


Protective effect of Lipoic Acid Amide in Experimental Mercurialism


Medical Institute


(Edited 13/6 1978)


For effective prophylaxis of professional mercurialism with measures of

a technically engineered and sanitary-hygienic order, the mass use of

current methods of individual pathogenic prophylaxis and therapy of

mercurial influences is necessary. Some of the most important research in

this field is the study of the effectiveness already approved and found new

more effective biological methods of prophylaxis and healing.

Currently the greatest perspectives are recognized means which in a

sufficiently expressed antidotal effect would not produce side effects (I.E.

Okonishniko et al; E.E. Rosenberg; O.G. Arhipov et al)

The given work was conducted with the goal of an experimental study of

the possibility of the use of lipoic acid amide as a means of individual

prophylaxis of mercurialism.

The works of B. E. Petrunkin, B. E. Anicimov, Y. M. Torchinckogo,

Crunert, Ueda and Nishimura, which give evidence of the presence of

protective effects of lipoic acid and its amide in the introduction of salts

of heavy metals into the body, were the theoretical preconditions to the

conduct of the experiment. Appearing as a biocatalyst of an oxidizing

decarboxylation of pyrogrape(?) acid in a composition of ferment, lipoic

acid forms a block with heavy metals. The introduction into the body of an

excess of lipoic acid or its amide produces a protective effect through the

relationship to this link of the changed process. The Iipoic acid activates

many fermenting systems in the body that explains its ability to easily

restore the groups --S--S--in--SH--SH--, i.e. to restore the activity of the

SH groups of thiol ferments are defeated by thiol poisons.

Methods. The studies conducted on 4 groups of white rats, (16 animals

in each group). The 1st and 2nd introduced intact animals, the 3rd and 4th

-- animals who underwent daily influence of mercury vapors in a

concentration of 0. 8 mg/m3. Lipoic acid amide, from the calculation of

10/kg, to supplements to the ration was introduced to the rats of the 2nd

and 4th groups in the 2nd reception (I0 minutes before and after the priming

tube).

Results. The dynamics of the mass of a body of animals of both control

groups on the extent of the whole experiment were approximately equal*. The

rats of the 3rd group after 8 weeks from the beginning of the trial of the

noting of a tendency of reduced body mass, towards the end of the experiment

it was identified lower, than in the control (196.0±5.72g while 2l2.3±3.96g

in the controI; P<0.05). The mass of the animals of the

4th group approached the mass of the control animals (205.9±4.46g)

In the 2nd and 3rd months of the experiment the maintenance of the

SH--goups in hemolizat(?) of the animals in the 3rd group (1238.14±55.81g

and 1362.23±47.23mm/100mi) was identified lower, than in the control

(correspondingly 1357.13±21.10 and 1598.38±32.48) and the animals of the 4th

group (correspondingly 1462.65±32.87 and I551.41±54.81).

Beginning from the 2nd month of the experiment the maintenance of the

protein in hemolizat?) that the animals of the 3rd had was identified as

lower, than in the control that the animals, of the 4th group had.

The animals of the 3rd group had a quantity of hemoglobin (compared to

the control), beginning from the 3rd month of the experiment that lowered

and became identified as lower in the 5th month of the experiment

(72.5±2.90% while 80.40±I.30% In the control). The animals of the 4th group

of had this indicator, which essentially did not differ from that which the

rats of the control had and towards the 5th month of the experiment

consisted of 79.20%±1.94%.

In the 4th month of the experiment the animals of the 3rd group

displayed statistically authentic signs of a dysfunction of thyroid ion.

From one side is the disclosed amplification of gas-volume (12.41% in

relation to the control; P
maximum swallowing of radioactive Iodine of thyroid ion (10.0±1.24 parts

while 14.35±2.20 parts in the control; P<0.0) and the period of biological

half-deduction(?) (3.05±0.61 days while 7.22±1.19 days in the control;

P<0.05), i.e. the signs of iron-hyperfunction of iron, and on the other side

is - displayed signs of iron-hyperfunction, about which the maximum

indicators of the swallowing of radioactive Iodine of thyroid Iron, which

were essentially lower than the control (13.00±0.70% against 21.10±1.45%;

P<0.05) gives evidence. The following facts give evidence about the

normalization of the function of thyroid iron in the animals of the 4th

group; the approach towards the controls use of oxygen, the maximum

swallowing (16.85±1.39% while 21.10±1.45% in the control) and times of

approach of the maximum swallowing of radioactive Iodine (12.60±1.40 parts

while 14.35±2.20 parts, in the control),the period of biological

half-deduction of radioactive iodine (5.28±0.40 days while 7.22±1.19 days in

the control).


*The animals of the second group by all studied indicators did not differ

from the animals of the first group, that let make the conclusion about

unharmfullness of lipoic acid amide in the given dose.


Towards the end of the experiment obvious signs of mercurial

intoxication in the 3rd group were observed- balding of separate portions of

the back, fits of clonic(?), spasms, breach of coordination of motions, cuts

of the abdominal and dorsal extremities, ulcers on the mucous membrane of

the mouth. In the animals of the 4th group there were only a a few spots of

balding of separate portions of the back. The death of animals in the 3rd

group began already in the 1st month from the beginning of the priming tube:

out of 13 animals toward the end of the experiment 5 died, and in the 4th

group beginning from the 3rd month of the trial -- 3.

In the animals of the 3rd group disclosed expressions of change in the

head's brain and internal organs. So, in the liver turned out a breach of

girder structure segments, swelling and an increase of hepotozites(?),

swelling of the proximal departments of coiled canals of the kidneys, nidus

swelling of sarkoplasm of muscular fibers of the heart.In the lungs was met

a widening of a portion of emphasima, hyperplastic interfolliculor weavings

of the spleen, in the adrenals- the hearty swelling of the kidney and

retinal zone of cortex.

In this way, the application of lipoic acid amide reduces the level of

expressiveness of changes springing up in the body during the chronic

influence of mercury vapors.

For the elucidation of the possible mechanism of the protective action

of lipoic acid amide, several of the toxic dynamics in the animals of the

3rd and 4th groups were studied.

In the 1st, 2nd and 3rd months of the experiment diurez(?) in the

animals of the 4th group was bigger, than in the animals of the 3rd group

that made the increase of the quantity of isolatable mercury in micrograms

conditional on one animal of this group. The concentration of mercury (in

milligram-percents) in the urine of the animals of the 4th group was in the

first month of the experiment 1.5 times, in the 2nd month of the experiment

-- 2.3 greater than in the animals of the 3rd group. The quantity of

secreted/isolated mercury in micrograms by one animal of the 4th group in

the Ist and 2nd months was higher than in the animals of the 3rd group,

corresponding to 1.8, and 3.3 times. In the 3rd and 5th months from the

beginning of the experiment the concentration of mercury in the urine of the

animals of the 4th group respectively consisted of 51 and 53% from the

concentration of it in the urine of animals of the 3rd group. The quantity

of the secretion of the uric mercury in micrograms by one animal of the 4th

group in the 3rd and 5th months from the beginning of the experiment

consisted of 84.0 and 47.5% from the given indicator of the animals of the

3rd group. One can consider that the quantity of secretion of mercury for

one day by one animal allows approximately defining its total quantity,

secreted by every animal of both groups for the extent of the whole

experiment. For 4 months (1st, 2nd, 3rd, and 5th months from the beginning

of the experiment) from the urine was secreted 13O.9 micrograms of mercury

by the animals of the 3rd group, and by every animal of the 4th group --

162.3 micrograms, i.e. 24.0% more.

The mercury secreted with the excrement (mean quantity of mercury,

secreted by every animal of the trial groups with excrement in micrograms

per day) gives evidence to the following facts: the mean quantity of mercury

secreted with the excrement by one of the animals of the 4th group for one

day in the 1st month of the experiment was more than in the (?) group, by

2.7 times, in the 2nd month -- by 2.3 times. For 4 months (Ist, 2nd, 3rd

and 5th months from the beginning of the experiment) every rat of the 3rd

group excreted 80.8 micrograms of mercury, and every rat of the 4th group --

175.6 micrograms i.e. for this period every animal of the 4th group excreted

mercury with it's excrement by 2.2 times more than every animal of the 3rd

group. If one sums the quantity of mercury excreted with their excrement and

urine by every animal of both groups for the 4 months of the experiment, one

receives the following indicators: by the 3rd group--211.7 micrograms, and

by the 4th group -- 337.9 micrograms, 59.6% more.

The concentration of mercury in the kidney (in the 5th month of the

experiment) of the animals of the 3rd group (in average 12.28±I.4

micrograms/gram) turned out I.5 times higher than in the animals of the 4th

group (in average 8.22±I.4 micrograms/gram).

The concentration of mercury in the kidneys of the rats of the 3rd

group (in average 1.59±O.19 micrograms/gram) increased by two times that of

the animals of the 3rd group (in average 0.75±0.09 micrograms/gram).

Conclusions. 1. Lipoic acid amide in a dose of 10mg/kg, used in the

course of 5 months of the experiment, did not show an unfavorable influence

on the general condition of the animals.

2. Lipoic acid amide reduces the toxic influence of the mercury vapors

on the bodies of the experimental animals.

3. In the base of protective action of lipoic acid amide lies on one

side, the connection and removal of mercury from the body, and on the other

side- the protection of thiol groups of a row of biologically active

unifications.

4. It is equally expedient with other measures of a hygienic and

healing prophylactic character to use lipoic acid amide in a capacity of

methods of pathogenic prophyIaxis and therapy of professional mercurialism.
 

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