Date:   5/2/2011 6:31:39 AM ( 13 y ago)
Hits:   3,542
URL:   https://www.curezone.org/forums/fm.asp?i=1806541

Hv, thanks for your organized time-help! ….for your more developed overview, eye, focus to more information, lucidhunt

http://www.mayoclinic.com/health/hemochromatosis/DS00455


Definition
By Mayo Clinic staff

CLICK TO ENLARGE
Hereditary hemochromatosis (he-mo-kro-mah-TOE-sis), an inherited condition, causes your body to absorb too much iron from the food you eat. The excess iron is stored in your organs, especially your liver, heart and pancreas. If you have hereditary hemochromatosis, the stored iron damages these organs, leading to life-threatening conditions such as cancer, heart problems and liver disease.
----------------------------------------------
http://en.wikipedia.org/wiki/HFE_hereditary_hemochromatosis


The hereditary form of the disease is most common among those of Northern European ancestry, in particular those of Celtic descent.
Signs and symptoms
Haemochromatosis is protean in its manifestations, i.e., often presenting with signs or symptoms suggestive of other diagnoses that affect specific organ systems. Many of the signs and symptoms below are uncommon and most patients with the hereditary form of haemochromatosis do not show any overt signs of disease nor do they suffer premature morbidity.[12]
The classic triad of cirrhosis, bronze skin and diabetes is not as common anymore because of earlier diagnosis.[13]
The more common clinical manifestations include:[5][13][14][15]
Fatigue
Malaise
Liver cirrhosis (with an increased risk of hepatocellular carcinoma) Liver disease is always preceded by evidence of liver dysfunction including elevated serum enzymes specific to the liver. Presence of Cirrhosis can also be discovered by the victim suffering from jaundice (yellowing of the skin).
Insulin resistance (often patients have already been diagnosed with diabetes mellitus type 2) due to pancreatic damage from iron deposition
Erectile dysfunction and hypogonadism, resulting in decreased libido
Congestive heart failure, arrhythmias or pericarditis
Arthritis of the hands (especially the second and third MCP joints), but also the knee and shoulder joints
Damage to the adrenal gland, leading to adrenal insufficiency
Less common findings including:
Deafness[16]
Dyskinesias, including Parkinsonian symptoms[16][17][18]
Dysfunction of certain endocrine organs:
Parathyroid gland (leading to hypocalcaemia)
Pituitary gland
More commonly a slate-gray or less commonly darkish colour to the skin (see pigmentation, hence its name Diabetes bronze when it was first described by Armand Trousseau in 1865)
An increased susceptibility to certain infectious diseases caused by siderophilic microorganisms:
Vibrio vulnificus infections from eating seafood or wound infection[19]
Listeria monocytogenes
Yersinia enterocolica
Salmonella enterica (serotype Typhymurium)[20]
Klebsiella pneumoniae
Escherichia coli
Rhizopus arrhizus
Mucor species
Males are usually diagnosed after their forties and fifties, and women several decades later, owing to regular iron loss through menstruation (which ceases in menopause). The severity of clinical disease in the hereditary form varies considerably. There is evidence suggesting that hereditary haemochromatosis patients affected with other liver ailments such as hepatitis or alcoholic liver disease suffer worse liver disease than those with either condition alone. There are also juvenile forms of hereditary haemochromatosis that present in childhood with the same consequences of iron overload.
 

<< Return to the standard message view

fetched in 0.02 sec, referred by http://www.curezone.org/forums/fmp.asp?i=1806541