Date:   4/17/2011 11:04:55 AM ( 14 y ago)
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Are substances or nutrients in foods which can prevent or slow the oxidative damage to the human body. When cells use oxygen, they produce free radicals best described as by-products. These free radicals can cause damage. Antioxidants have been reported to act as "free radical scavengers" and can prevent and repair damage done by these free radicals. Health problems such as arthritis, heart disease, macular degeneration, diabetes, cancer and other detrimental disease, may all caused by free radical damage.

CANCER, ANTIOXIDANT STUDIES & NOBLE METALS APPLICATIONS OF PLATINUM GROUP METALS IN CANCER AND HIV TREATMENT

Reviewed by Christian G. Hartinger
Institut des Sciences et Ingénierie Chimiques, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland; and University of Vienna, Institute of Inorganic Chemistry, Währinger Str. 42, A-1090 Vienna, Austria; christian.hartinger@epfl.ch
Platinum Metals Review
Volume 52 Issue 2 April 2008 Pages 96-99
DOI 10.1595/147106708X298296

Antitumour and Anti-HIV Applications of PGMs
With regard to platinum group metals (pgms), an overwhelming number of presentations at Dalton Discussion 10 focused on their application as antineoplastic agents. Platinum complexes are applied in half of all chemotherapeutic schemes against a wide range of tumours, although they are effective against only a handful of tumourigenic diseases. Keynote presenter Chi-Ming Che (University of Hong Kong, China) et al. reported on their recent developments of platinum(II), ruthenium(II), ruthenium(III) and ruthenium(IV) complexes alongside non-pgm compounds (gold, iron and vanadium) as anticancer and anti-HIV agents (4). Che presented Pt complexes which bind non-covalently to biomolecules, and are capable of binding in an electrostatic or hydrophobic manner as well as via intercalation. Some of the complexes were found to be up to 100 times more potent in vitro than cisplatin. Furthermore, aminoalcohol-platinum complexes were proposed as protein-staining reagents in sodium dodecyl sulfate (SDS)-polyacrylamide gels, due to their high binding affinities to proteins, and protein interaction is also accompanied by an enhancement of the emission. In addition, Ru complexes with quinonediimine as auxiliary ligands were shown to intercalate into DNA, but were found to exhibit mild cytotoxicities of about 200 μM against epidermal KB-3-1 and KB-V-1 carcinoma cell lines. A ruthenium-oxo oxalato cluster was presented which exhibited promising anti-HIV properties, being about ten times more active than the common HIV-1 RT inhibitor 3′-azido-3′-deoxythymidine-5′-phosphate.

Other Metals
Besides the talks mentioned above, there were numerous fascinating presentations and posters on applications of other metal compounds for medicinal purposes. These include gold, titanium, rhenium and iron complexes for cancer chemotherapy, CO-releasing molecules, radiometallodrugs for diagnosis and therapy (for example, copper complexes for positron emission tomography (PET) imaging and technetium binding to peptides), gadolinium complex-based contrast agents, zinc and copper complexes as probes for in vitro fluorescence imaging and α-emitters such as 213bismuth, 211astatine and 225actinium as therapeutics.

Concluding Remarks
In summary, a broad variety of applications in metals in medicine and healthcare was presented, with Pt, Ru and other metal-based drugs demonstrating the potential to become the major treatments for some common diseases. Dalton Discussion 10 was a very interesting conference at a pleasant venue in the old city of Durham, and had an appropriate size to benefit from the special conference mode with its focus on discussion. All the contributions can be read in the special issue of Dalton Transactions, published in autumn 2007 (2).

Dr. SIMONCINI reports:
When compared with the whole universe of fungi forms mycetes that are pathogenic for humans are not very numerous.

They usually cause diseases called mycosis, which are commonly divided into superficial (when the infection is limited to the cutis, body hair, hair of the head, and nails) and deep (when the infection attacks internal organs such as lung, intestine encephalus, bones, and others).

The fungi are generally classified as:
•1. dermatorphytes, causing afflictions that are typical of the epidermis (tinea)
•2. sporotrichum schenckii, which are also almost exclusively located on the epidermis
•3. Criptococcus neoformans, responsible for a diffused infection of the lung (the organisms are inhaled with dust) as well as chronic meningitis
•4. Histoplasma capsulatum, which in humans produces the nodular cutaneous form, mucous form, the pulmonary form, and the systemic form.
•5. Actinomycetes, with pathogenic action on the cutis, lungs, and intestine
•6. Chrysosporium parvum (causal agent of the adiasphyromycosis), a cosmopolitan disease where the respiratory tract constitutes the primary and only localization of the infection
•7. Aspergillus fumigatus, cause of the Aspergillosis, whose most frequent location is in the lungs, followed by a secondary location in the cerebrum and in the kidneys
•8. Paracocci dioides brasiliensis, which causes the paracoccidioidomycosis, a primary pulmonary infection that can become diffused in immuno-depressed patients
•9. In recent years, Pheoiphomycosis ialiphmycosis, pennicilinosis (marneffei), zigomicosis and other rare mycotic infections are acquiring more and more importance since they can be responsible for pathological scenarios that are sometimes very serious because of the compromised conditions of immuno-compromised patients.
•10. Candida, both as Albicans and as any other pathogenic stock which afflicts the cutis, nails, internal mucus membranes (oral cavity, vulvar vaginitis, urethritis, balanitis, perianal infection), bronchi and lungs.
Candida is also responsible for causing generalized forms of septicemia of remarkable gravity.

The gravest disease of humanity is, therefore, hidden within this grouping of fungi. Some further analysis will make it easier to identify the cause. Dermatorphytesand sporotrichum are responsible for a morbidity that is too specific. We know from experience that Actinomycetes, Criptococcus, Hystoplasm, Chrysosporium, Paracoccidioides and other causal agents of Pheoiphomycosis ialiphmycosis, pennicilinosis, zigomicosis are very rarely part of a pathological context. Finally, Aspergillus can be considered a variation of Candida. Only one of the six kinds described above remains as the sole responsible agent for tumors: Candida

The Best Fungus and Virus killer is and always will be Colloidal Silver atoms.

Scientists in Japan did research on noble metals such as gold, iridium, ruthenium, rhodium and platinum and have determined that the root elements in many fruits and vegetables that have a medicinal effect on the human body are the above noble metals in the form of trace elements, AKA Antioxidants.

Bristol Myers Squib announced in the early 1980’s that Iridium and Ruthenium are anti cancerous.

When Iridium and Ruthenium are reduced to atomic size particles you have pure unadulterated Iridium and Ruthenium Antioxidants in Trace Mineral form.
Cancer and Free Radicals have to be dealt with at the atomic level.

Unfortunately many medicines today are made with nano particles and are not at the atomic level, while they may have some temporary effect on cancer cells and or free radicals, nanoparticles simply bounce off the intended targets because they are just too large.

The answer to this problem is Colloidal Iridium and Ruthenium, in 4000 PPM or higher.

 

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