Date:   9/6/2010 4:31:53 PM ( 14 y ago)
Hits:   1,878
URL:   https://www.curezone.org/forums/fm.asp?i=1685280

Those papers describe the role of Leukotrienes in the inflammation but they do not prove nor study the primary cause of the inflammation. As I wrote earlier, you did not really adress that crucial point:

- The whole idea that reduction of the inflammation by downregulation of leukotrienes (by minimizing AA etc) leads to a decrease of atherosclerotisis in patients, rests on the assumption that it is the overactive immune system itself with the leukotrienes and all that that are causing atherosclerosis.

Even if that hypothesis were true then there is a question what is causing the immune system to become overactive? Are humans built such that some increase in the immune activity caused by some dietary change (i.e. more animal fat) were supposed to kill us by heart diesease where as a decrease were supposed to kill us by infections? I doubt! If they want to prove that atherosclerosis is caused by the immune system gone amok then they must find out what exactly does cause the immune system and the ensuing endotheliarl repair to go amok! Immune system is homeostatic - it stabilizes itself.

On the other hand, if the endotheliar repair processes carried out by the immune system involiving leukotrienes are only a reaction to the injury, then their atherosclerotic result should be more dependent on the original rate of the injury rather than the property of the immune system itself. The fact that the leukotriene effect was so small - only 11% (in one of the study you quoted) would point towards that interpretation. The fact that wheat correlated strongly ( 60%) with ischaemic heart disease in China (and negatively with AA containing animal fat, and with much lower correlations with cancer and infections) seems to be pointing out towards some potent injury-causing factor associated with the wheat itself rather than being caused by the immune system directly. If the effect were caused only indirectly by wheat acting upon the immune system then there should have been an impact of wheat on cancer and infectious disese mortality. There wasn't , or was much lower.

Some scientists would agree with your view, some would probably agree with the opposite. The fact that there is a degree of confusion among scientists with regards to the causative or non-causuative role of the leukotrienes can be illustrated by this paper:

Cysteinyl-Leukotrienes in Cerebrovascular Disease / Angels and Demons?

http://atvb.ahajournals.org/cgi/content/full/28/5/805


Quote:

A potential stroke-protective effect of proinflammatory mediators is definitively an exciting thought. However, although promoter polymorphisms only can provide a suggestion of such a link, further mechanistic studies are needed before judging the cysteinyl-LTs as either angels or demons in cerebrovascular disease.
 

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