Date:   3/22/2010 3:13:56 AM ( 14 years ago ago)
Hits:   6,265
URL:   https://www.curezone.org/forums/fm.asp?i=1594080

It is a mistake to believe the people attacking you can think clearly enough to be logical if only given the right argument. This is probably an unconsidered assumption in your head. Don't get worked up about it, and allow yourself to see how they're illogical and emotionally motivated. Address them within that context.

I did some research and there is a possible mechanism to differentiate orally administered from anally administered caffeine: The hepatic portal system. This series of veins connects the gastrointestinal tract to the liver.

``Many drugs that are absorbed through the GI tract are substantially metabolized by the liver before reaching general circulation. This is known as the first pass effect. As a consequence, certain drugs can only be taken via certain routes.''

I don't know how caffeine works. Does it require activation? When and where is it metabolized, and with what efficiency? Is the first step metabolite inactive?

The hepatic portal system may actually be the same path by which orally administered drugs are introduced to the system. I am unsure. Is there a different degree of passage through the liver for upper GI v. lower GI despite both possibly using the hepatic portal system?

Something to note is that palmitic acid from coffee is said to have an effect on the liver. It could be that there is an impact derived from this alone, and that one might even forego the caffeine. Find a different source of palmitic acid. Even then, though, this could still be more "button mashing" without a good understanding of the ultimate effects. It seems it has something to do with acetyl-CoA. Could be the caffeine crashing is propped up by metabolic overdriving. Coffee palmitic acid to liver -> acetyl-CoA carboxylase inhibition -> elevated acetyl-CoA -> increased fat metabolism. If this is what's going on, you can expect more ketone bodies. (Advocates! You can get ketone test strips from the local pharmacy! Are your levels elevated?) Things to be careful about, then, would be heightened ketosis or even ketoacidosis (breath smelling like fruit or nail polish remover, increased blood acidity, possibly elevated insulin levels) and phosphofructokinase deficiency (exercise-induced muscle cramps and weakness, dark urine, high uric acid in the blood, gout, renal failure). Anyway, that's my guess. Oh, and beware fatiguing adrenals with caffeine while doing the rest of this overdriving. You might get the same good feeling from a milk enema (milk has palmitic acid). Or maybe the palmitic acid levels are much higher in milk and would result in a dangerous degree of button mashing? Try a dilute milk enema, maybe. You know, like a decaf cuppa joe with a dash of cream, Sugar optional.

Anyway, Hveragerthi, don't rely on the advocates who base their beliefs on hearsay to be the ones to give you the information you need. Nor should you condemn coffee enemas outright because the advocates are underinformed or misinformed (re Gerson's track record, e.g.). (You don't actually seem to be doing this, though.) You'll need to do your own research.
 

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