Date:   3/11/2010 1:43:22 PM ( 14 y ago)
Hits:   5,702
URL:   https://www.curezone.org/forums/fm.asp?i=1588319

Here are 2 studies which show that

1. fenugreek protects against formation of cholesterol gallstones in mice eating a high-cholesterol diet
2. fenugreek dissolves cholesterol gallstones in mice on a normal diet with added fenugreek

The studies were carried out by the same team which found that garlic and onion had similar effects on gallstones in mice. Garlic/onion study 1, garlic/onion study 2. Ideally, I would've liked to see different teams of researchers for confirmation, but I'm probably just paranoid. The results are probably legit.

Note in the studies below that quite extreme amounts of fenugreek were given the mice; from 5-15% of their diet. Fenugreek, as far as I know, is mostly used as a spice (e.g. in curry) and has a bitter taste on its own, so it'd probably be hard to include even 1% fenugreek in a human diet. It is also sold in capsules as a supplement, which I'll look into taking as part of a strategy to dissolve and prevent gallstones.

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Dietary fenugreek seed regresses preestablished cholesterol gallstones in mice.

An animal study was carried out to evaluate the influence of dietary fenugreek seeds on regression of preestablished cholesterol gallstones (CGS). CGS was induced by feeding a high-cholesterol diet for 10 weeks. After CGS induction, the animals were maintained for a further 10 weeks on experimental diets of high cholesterol, 6% fenugreek powder, 12% fenugreek powder, or basal control. Incidence of CGS and its severity were evaluated at the end of this feeding regimen. The incidence of CGS was significantly lowered as a result of dietary fenugreek seeds, the extent of regression being 61% and 64% in the low and high dose groups compared with 10% regression in the basal control group. The antilithogenic influence of dietary fenugreek was accompanied by significant reductions of more than 35% in serum cholesterol concentration. Hepatic cholesterol concentration was also profoundly lowered by dietary fenugreek, being 53%-63% lower than that of the basal control diet. Biliary cholesterol concentration was significantly lower as a result of dietary fenugreek during the post-CGS induction period, resulting in a decreased cholesterol:phospholipid ratio (0.44 and 0.40 compared with 0.79 in the basal control group). Biliary cholesterol : bile acid ratio was lowered by 67% and 73% upon feeding fenugreek, significantly lower than that in the basal control group. The cholesterol saturation index in the bile was also beneficially lowered by fenugreek treatment during the post-CGS induction period (the index was 0.90 and 0.42 compared with 1.86 in the basal control group). The present study provides evidence of the potency of hypolipidemic fenugreek seeds in regressing preestablished CGS, and this beneficial antilithogenic effect is attributable to its primary influence on cholesterol levels. This finding is significant in the context of evolving a dietary strategy to address CGS, which could help in preventing the incidence and regression of existing CGS and controlling possible recurrence.

http://www.ncbi.nlm.nih.gov/pubmed/19794519

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Fenugreek seeds reduce atherogenic diet-induced cholesterol gallstone formation in experimental mice.

Dietary hypocholesterolemic adjuncts may have a beneficial role in the prevention and treatment of cholesterol gallstones (CGS). In this investigation, fenugreek (Trigonella foenum-graecum) seed was evaluated for this potential on the experimental induction of CGS in laboratory mice. CGS was induced by maintaining mice on a lithogenic diet (0.5% cholesterol) for 10 weeks. Fenugreek seed powder was included at 5%, 10%, and 15% of this lithogenic diet. Dietary fenugreek significantly lowered the incidence of CGS in these mice; the incidence was 63%, 40%, and 10% in the 5%, 10%, and 15% fenugreek groups, respectively, compared with 100% in the lithogenic control. The antilithogenic influence of fenugreek is attributable to its hypocholesterolemic effect. Serum cholesterol level was decreased by 26%-31% by dietary fenugreek, while hepatic cholesterol was lowered by 47%-64% in these high cholesterol-fed animals. Biliary cholesterol was 8.73-11.2 mmol/L as a result of dietary fenugreek, compared with 33.6 mmol/L in high-cholesterol feeding without fenugreek. Cholesterol saturation index in bile was reduced to 0.77-0.99 in fenugreek treatments compared with 2.57 in the high-cholesterol group. Thus, fenugreek seed offers health-beneficial antilithogenic potential by virtue of its favourable influence on cholesterol metabolism.

http://www.ncbi.nlm.nih.gov/pubmed/19935901 

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