I think I responded to the other post I read about someone using safflower oil instead of olive oil, and I want to post the same response to you. It would appear that safflower oil is not as safe to use as olive oil. You can find information about it on Dr. Mercola's website, but I will post a reference for you about it. Safflower oil and polyunsaturated oils in general are cancer-promoting in large quantities. Olive oil, on the other hand is a much healthier oil. I myself would not take the chance of using any other oil than olive oil.
Here is some info and links: http://www.mercola.com/2002/may/22/fish_oil.htm
I strongly recommend avoiding sunflower, corn, soy, safflower, and canola oil, and products that contain these oils. This also means no hydrogenated or partially hydrogenated fats, no margarine, no vegetable oil, and no shortening. These oils are full of omega-6 fats and will only worsen your omega-6 to omega-3 ratio.
Acceptable oils include high-quality extra virgin olive oil, coconut oil, avocados, and organic butter... or better yet, grass-fed organic butter.
Animal studies have shown that a diet high in some kinds of fat (such as corn or safflower oil) increases the risk of colon cancer, which depends on both the amount of fat consumed and the type of fatty acid it contains. Additional studies have indicated that dietary fish oil inhibits or prevents colon cancer.
Rats given a diet high in safflower oil had more premalignant changes in the linings of their colons and a higher incidence of colon cancer than those fed a diet high in fish oil or olive oil. Examination of colon tissue revealed that a diet high in fish oil or olive oil reduced the bowel tissue concentrations of arachidonate, a substance that enables the formation of cancer, to a greater extent than did a diet high in safflower oil.