Not sure about the histamine connection. I've never read anything implicating low/high histamine count in bb. However, it is associated with Depression and schizophrenia--then again, so are a lot of things. I'm a strong believer that a person's emotional/psychic life can wreak havoc on their physical lives, causing all sorts of hormonal, glandular, neurological problems. I would sooner believe that someone's histamine levels are deficient/excessive due to their emotions before I would believe the opposite.