I cannot help you with your questions... but I can tell you that I have done a weekly coffee enema for the past two weeks and will be doing a third in a day or two. Each has produced very positive results... almost surprising results considering that I thought I was clean (bowels). I also believe that it will, with regular use (what that is I suspect varies with the individual) clean the liver and gallbladder as well as the pancreas.
I suspect, but do not know that the coffee enemas must contribute to the unblocking of the pancreas and spleen. I have read where it is very beneficial for individuals diagnosed with pancreatic cancers.