I agree that early detection should not affect survival. The disease started many years before the detection (pre clinical period). The medical establishment measures survival from the detection (clinical period only) and does not account for the pre clinical period. This way any technological progress (for example palpation to mammography) improves survival. Accounting for the pre clinical period is required and then early detection will not affect survival. The secrets of cancer, however, are better revealed if hazard rate is used. It shows that something, which is unique to cancer. HR rises in the first three years of the disease and then declines. There is more in cancer than its tumor. It is an interaction between host and a viral infection. The host response for a prolonged viral infection is a tumor. For more on that please see presentations on you-tube from Professor Zajicek.