My friend from another forum is cured from a huge scattered hyper infection. He believes it was River Blindness Worms.
He had to treat for over a year.
That depleted them. Then he spent six months straight taking Ivermectin daily and several large doses of moxidectin which messed him up neurologically. He was stumbling, but as he was in hospitalised at the time, they just put him into observation.
He is cured but he will dose every six months for life. This is recommended.
I have learned from him that it is being consistent and long term that brings a cure, not extremes for short term. By long term I mean a year or a year and a half.