When I started out at 50mg a day I began having horrible detx headaches about 9 days in. I had to up my dosage to 100 mg to negate it. I stayed above 100 for several months. I experimented with a few days off recently and when I began again I started taking 12.5 mg a day. Been on this for over a week and I am not having the headaches and other symptoms I had when I previously took lower dosages. I was afraid that I would never be able to stop or lower my dose and now I know I can. I guess I got enough crap out now that I can maintain a low dosage. My fatigue has been better on the lower dose than it was on the higher. I was debating on giving up on Iodine altogether so I am pleased to know I don't have to mega dose now. Makes things a lot easier.