I worked with a doctor during my treatment and he suggested 14 days. I was told t would be really hard on my body and he wasnt kidding - I dragged myself into his office three times a week and he would check on me. Second round was even rougher- ended up in emergency twice with super high blood pressure and dehydration. I went on the advice of my doctor. Of course when they found out what I was taking and what for they sent for a shrink. I left without speaking to him and called my doctor to let him know I was released to go home as my blood pressure stabilized. I had a severe systemic infection and even though the prazi was the toughest to be on - felt sick and achy and feverish pain couldnt sleep it worked the best out of the series that I had used.