"The incidence of autoimmune, allergic and inflammatory disease is increasing due to as yet unidentified environmental factors related to western living conditions. Here, I propose that alterations in the gut microbiome, acting via regulatory T cells (Tregs), may be responsible for this epidemic."
One "as yet unidentified environmental factor related to western living conditions" will be the Standard American Diet (SAD). Antibiotic exposure is already heavily identified with gut imbalances that lead to diabetes, obesity, and cancer.