Thanks so much for responding. I am/was concerned that the Meds would not be able to reach the upper dermal layer. And, after two weeks into the protocol, I wasn't experiencing many overt signs of die off in skin. Until I started applying to my skin. My understanding is that DMSO acts as a carrier, which is why I add to the mix. I immediately had results when I applied to my skin, which is why I decided to post. When u start the protocol, make sure to take NAC supplement. I did not see it referenced as a supplement in ICU material. While being treated by LLMD, he would insist that I take 1-2 NAC twice a day while taking any anti fungal or patients Meds that could hurt liver. Despite extremely high dosages, my liver values were always in the normal range.