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Re: Is TMG good for lowering histamine levels?
 

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Hveragerthi Views: 11,894
Published: 11 years ago
 
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Re: Is TMG good for lowering histamine levels?


 I was under the impression that it was until I read this


"Theoretically Trimethylglycine will make Sam-E, but it's not guaranteed, additionally it is a super methylator. If over methylation is a problem, then trimethylglycine may present a problem because when trimethylglycine loses a methyl group to homocysteine, it gets converted to dimethylglycine (DMG) and this would something to avoid with overmethylation."

Actually TMG does break down in to SAMe then in to glycine.  So it goes TMG to DMG to SAMe then in to glycine as it loses methyl groups.

And TMG can contribute to the body's antihistamine activity.  It does this by methylation, which is needed for epinephrine production.  Epinephrine is the body's own natural antihistamine.

I also read that it isnt as good as say Sam-E or methionine because it isnt sulfur based and high Hs need sulfur increases. Thoughts?

I disagree.  SAMe breaks down in to homocysteine, which is remethylated back in to SAMe.  What they are referring to is the transsulfuration pathway resulting in the formation of sulfur bearing amino acids provided sufficient B6 is present.  But sulfur bearing amino acids are plentiful in the diet as well so we do not need to worry about production of these as much.  Personally I think converting excess homocysteine back in to SAMe makes more sense than converting it in to sulfur based amino acids that are readily available in the diet.

And TMG can provide 3 methyl groups to reconvert  the homocysteine back in to SAMe.

 

 
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