Hello...not sure what Oxypowder is but the first and well only time I had a colonic done I woke up the next morning and I looked horrible. Felt ok but looked like I got punched out. My eyes were soooo swollen and kind of ting of darkness. I called the lady who did the colonic and she said it was from a big release of toxins. She said it does happen if toxins are released too quickly. I was doing a parasite cleanse at the time as well so not sure if the mixture did it or not. But it all went away by the next day.