Rotating antifungals the worst thing you can do.

Hi guys,
Before to post this in this forum, I did some research and emailed two microbiologists about this topic. I wanted to be sure to bring a right information to you. In fact, I knew and learned about it since I read the Dr. Crandall's material. In spite of, I totally believe in Dr. Crandall, I emailed Prof. Ayers and Lee, both are recognized microbiologists researching microbies for years. Both agreed the rotation induce resistence. Rotating antifungals actually builds up yeast strains that have multiple resistence mutations. Microbies mutate at a rate of 1 in a millon even taking or not taking antifungals. That means for every one millon yeast, there will be one yeast cell with a different mutation in gene in its DNA. These yeasts will have a mutation of resistence to some antifungals. Increasing the doses and keeping the effective antifungal for long enough, will kill these mutated strains. In order to avoid resistant strains, you should treat the infection early with an effective antifungal and for long enough to eradicate the infection. Something similar occur when you change or rotate Antibiotics to eradicate a bacterial infection. In fact, antifungal rotation stimulate fungal resistence and you end up with a multiple resistant strain to several antifungals. I got this explanation from a very reputable source and confirmed by two more.
Jorge. Tweet