Yes, the difference between the grandulars and the pharmaceutical version is that in the grandulars your dosage may vary and you wont know exactly how much t4 and t3 you are getting with each dose. I read about it and decided to try a pharmaceutical version made in asia that you can order from a reputable online pharmacy called "thyroid-s". It is very affordable, i got a 4 month supply for under $50, took one week to arrive.