If you're talking about Lymes disease from a tick bite {I think}, I believe that is a parasite in the blood. I can't remember where I read that... I recommend juicing as a daily part of your diet, just to keep you healthy. I would think the Master-Cleanse would help detox you, but again, I'm gonna say pre-cleanse with a juice fast cuz your detox crisis may be intense. Maybe not, but make it easy on yourself. I have a lung prob & am going onto a long juice pre-MC diet. My 1st Master-Cleanse was intense. Just flu-like feelings, but juicing first will make my next loooong fast easier. Keep us posted as we love success stories here! :) I wish you all the best. ~Rebeckah.