>>>People with defects in sulfation (a phase 2 reaction) are likely to have an aberrant response to DHEA supplementation. THe response to oral DHEA will be brief and greatly exaggerated. Breast tenderness or pain is common in women with this problem. Taking sulfate (magnesium sulfate, gluosamine sulfate, magnesium sulfate infections) may correct these problems.
Low sulfate indicates a need to supplement it (e.g. by eating 1/4-1/2 tsp Epsom Salts , or a gram or two of glucosamine sulfate, sodium sulfate, etc.) Do not take any
sulfate containing supplements at the same time as calcium supplements because they will form insoluble precipitates. Sulfate can also be supplemented by taking Epsom Salt baths. Those with very low sulfate will not metabolize oral DHEA properly, and poor response such as a woman experiencing breast pain from 10 mg a day of DHEA indicates phase 2 sulfation should be investigated. Molybdenum supplementation may help the body make more endogenous sulfate.
Elevated plasma cysteine, sulfur food reactions , or reducted magnesium or sulfate levels indicate plasma taurine levels should be investigated. If they are low supplementation will relieve ansiety, improve toxin excretion in the bile, assist digestion. etc. The taurine level is determined as part of most plasma amino acid tests.