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Re: MMS non-activate
 

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Jonsher_uk Views: 3,390
Published: 12 years ago
 
This is a reply to # 1,421,831

Re: MMS non-activate


From what I gather the breakdown after ingestion of ClO2 is to over 80% chloride after 72 hours and less than 1% chlorate. Not arguing with you of course though :)

from the atsdr report


3.4 TOXICOKINETICS
Although no data were located regarding absorption following inhalation exposure to chlorine dioxide,
little absorption of parent compound across lung tissue would be expected due to the highly reactive
nature of chlorine dioxide. The rapid appearance of 36Cl in plasma following oral administration of
chlorine dioxide (36ClO2) or chlorite (36ClO2-) has been shown in laboratory animals. Using 72-hour
urinary excretion rates for 36Cl, absorption rates of 30–35% of intragastrically administered chlorine
dioxide or chlorite have been estimated. Limited animal data indicate the presence of 36Cl in plasma
following dermal application of Alcide, an antimicrobial compound containing sodium chlorite and lactic
acid that rapidly form chlorine dioxide when mixed together. In rats, absorbed 36Cl (from 36ClO2 or
36ClO2- exposure sources) is slowly cleared from the blood and is widely distributed throughout the body.
Chlorine dioxide rapidly dissociates, predominantly into chlorite (which itself is highly reactive) and
chloride ion (Cl-), ultimately the major metabolite of both chlorine dioxide and chlorite in biological
systems. Urine is the primary route of 36Cl elimination, predominantly in the form of chloride ion.


3.4.3.2 Oral Exposure
Both chlorine dioxide and chlorite are primarily metabolized to chloride ion. At 72 hours following
single oral (gavage) administration of radiolabeled chlorine dioxide in rats, chloride ion accounted for
approximately 87% of the radioactivity that had been collected in the urine and 80% of the radioactivity
in a plasma sample (Abdel-Rahman et al. 1980b). Chlorite was the other major metabolite, accounting
for approximately 11 and 21% of the radioactivity in the urine and plasma samples, respectively.
Chlorate was a minor component of the radioactivity in the urine. Similarly, chloride ion accounted for
approximately 85% of the radioactivity in the 72-hour urine collection of rats that had been orally
administered radiolabeled chlorite; the remainder in the form of chlorite (Abdel-Rahman et al. 1984a).
Both chlorine dioxide and chlorite, being strong oxidizing agents, are most likely rapidly reduced in
biological systems mainly to chloride ion. Bercz et al. (1982) demonstrated this reduction for chlorine
dioxide that was introduced into saliva obtained from anesthetized monkeys.
 

 
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