Be assured that no on all these forums has had that happen yet. Not that I've read. The parasite cleanse (black walnut,wormwood, cloves) kills what is in your intestines, the Bowel Cleanse pushes it through, daily, I don't think 30 or 40 years of stuff will come out all at once. The zapper, I thought, kills what is in your skin and organs. If I am wrong, someone please explain. I thought only extreme cases like that would only happen in the tropical amazon. The liver cleanse is what I would not do on an important business day. I like the b@p shakes better than the chinese herbal bulk formula. The bulk formula worked really good, but while doing my work duties I needed to get to the bathroom in, like 30 seconds or less. I hated living like that.