I'd get the toe warm and wet with hot water and then put the tube from the generator on the area directly. Also you could just put the toe in some hot water and put the tube from the generator in with the water so you get a ozonated bubble bath on the toe. Skip the ozonate oil. Nothing works better than pure ozone on the area. I fought athletes foot with ozonated olive oil for over a year and it always came back. Then I just put the tube from the generator between my toes and now it's permanetly gone after 4 applications.