Let me try this first. You really have to have an understanding of this.
In short, the pancreas is overproducing(redirecting) insulin due to inflammation/allergy, which means it is overproducing IGF-1. The lips(keratinocytes) are insulin resistant because so much insulin was being directed towards it, every time the cell becomes more resistant to it. What i'm trying to do is lower the pancreas overproducing insulin/IGF-1 and stop the lips keratinocytes from being insulin resistant. I'm currently looking at insulin-sensitizing agents, which can be applied topically. This can stop the cells from being insulin resistant(unlock the cells) and diet can correct the overproducing(or redirection) of insulin/IGF-1. Why i want to make the cells
non -insulin resistant is because these cells can't control the IGF-1 coming from the pancreas.
If you don't understand it's fine, everything i've wrote is from research. It may not show up as high levels of insulin on a blood test but the insulin being produced by the pancreas may be redirected to the lips in an attempt to heal them, which is more than needed.