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Re: Oral Glutathione - useless
neo... Views: 1,896
Published: 14 years ago
This is a reply to # 1,006,144

Re: Oral Glutathione - useless

I am not convinced either way...but this is interesting...

. Hagen, T.M., Wierzbicka, G.T., Sillau, A.H., Bowman. B.B., and
Jones, D.P. Bioavailability of dietary glutathione: Effect on plasma
concentration, Am. J. Physiol, 1990a, 259: G524-G529. PMID: 2221062

"Plasma glutathione (GSH) concentration in rats increased from
approximately 15 to 30 microM after administration of GSH either as a
liquid bolus (30 mumol) or mixed (2.5-50 mg/g) in AIN-76 semisynthetic
diet. GSH concentration was maximal at 90-120 min after GSH
administration and remained high for over 3 h. Administration of the
amino acid precursors of GSH had little or no effect on plasma GSH
values, indicating that GSH catabolism and resynthesis do not account
for the increased GSH concentration seen. Inhibition of GSH synthesis
and degradation by L-buthionine-[S,R]-sulfoximine and acivicin showed
that the increased plasma GSH came mostly from absorption of intact
GSH instead of from its metabolism. Plasma protein-bound GSH also
increased after GSH administration, with a time course similar to that
observed for free plasma GSH. Thus dietary GSH can be absorbed intact
and results in a substantial increase in blood plasma GSH. This
indicates that oral supplementation may be useful to enhance tissue
availability of GSH."

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