Witschi and coworkers found that "it is not possible to increase circulating glutathione to a clinically beneficial extent by the oral administration of a single dose of 3 g of glutathione."However Glutathione precursors such as undenatured whey protein and N-acetyl-cysteine have been shown to increase glutathione content within the cell. N-acetylcysteine is a generically available supplement which has been demonstrated to increase intracellular reduced and total glutathione by 92% and 58% respectively.
This is intersting about S.O.D.
Glisodin is a cantaloupe melon extract rich in vegetal superoxide dismutase covered by polymeric films of wheat matrix gliadin. This is the only proven orally effective delivery of SOD.
In the research, this SOD/gliadin complex is also called Glisodine and Oxykine. It is the same material.
The natural process of oxygen metabolism results in the development of reactive oxygen species (ROS). In order to protect the body from highly toxic ROS, the body has acquired anti-oxidative stress mechanisms, or an antioxidant defense system. These anti-oxidative stress mechanisms are localized in tissues and inside the cells where ROS are generated.
If the amount of ROS exceeds the limit of the antioxidant defense system of the body for any reason, the damage to the cells results in not only aging but also in some pathological processes.
The powerful natural antioxidant enzyme superoxide dismutase (SOD) acts at the very source of the chain reaction that produces (ROS). SOD therefore constitutes the first and one of the main links of the defense process against free radical damage.
Therapeutic administration of SOD to address insufficiency has not been effective orally. SOD has an extremely fragile molecular structure, and non-protected SOD is destroyed by stomach acids and digestive enzymes.
This limitation has been overcome with the use of gliadin, a wheat protein recognized as a carrier for controlled drug release. The complex of gliadin with a vegetable sourced SOD (a melon, cucumis melo) has resulted in an orally effective delivery system.
Glisodin has been shown to be orally effective in several in vivo studies on animals as well as in clinical trials. In these studies, glisodin has been shown to preserve the antioxidant activity of the SOD enzyme, resulting in an increase in organ and circulating SOD levels. Further, in vivo and clinical research has substantiated the anti-inflammatory and immunomodulatory properties of glisodin.