l-Glutamine does help me
I've had chronic constipation on and off for many years (although I ignored it for a long time, as I didn't regard it as a real problem). I was getting desperate recently. I could restrict my diet to only the right things, drink fluids until I was so bloated I looked pregnant, and take all the supplements that are supposed to help, until I overdosed. But I still could not have a bowel movement, unless I did an enema (I don't use stimulant laxatives or medications, and I know not to do enemas too frequently, for similar reasons).
Then one day I decided to try a couple grams of some l-Glutamine in water, since I kept seeing it recommended for the liver/gallbladder (I have GB sludge). And then an hour or so later, it was like my large intestine finally remembered how to do peristalsis. That was 5 days ago, and I've been able to go to the bathroom on 5 out of 6 days since. I take 1-3 grams of l-Glutamine mixed in water. On the day I couldn't, I took it much later, after already having taken a bunch of other stuff (too much--my liver is still recovering from that, and I learned my lessson).
It's interesting how each of us can have a different piece of the puzzle missing, why things don't move. I hope this helps somebody. It does seem kind of weird to me, as l-glutamine is known to *cause* constipation, if too much is taken. But "too much" is different for everybody. Correct dosage seems to vary wildly between individuals. I weigh about 52 kg, and I have a history of leaky gut and other digestive difficulties, due to many years of unhealthy eating and drinking habits. Also, take it alone in plain water (not hot), away from anything else, unless you have l-alanyl-glutamine (I've never tried that one, but I've read).