I recently did an 18 day Master Cleanse (my first) and feel great. I have not given up meat yet and wonder if I'm doing myself any harm by taking digestive enzymes when I have a meal that includes meat, food that's in Fat, or Carbs? I read the bottle thoroughly and there are no limits on how long you can take them or side effects. Just says take 2 either before or after a fatty, or high carb meal. I wonder if any of you have any wisdom on the subject of digestive enzyme supplements.