I have just found out about whats labeled histadelia and I find that I have a ton of strikingly symptoms. That said I have also read a few people who think its some fantasy internet created illness as there is no recognition on pubmed/from real doctors. Can I get any sort of confirmation that this is legit or isnt? If anyone has had it and had any type of success in treating it, what has helped.
I would say yes, it is a real disease. Just like hormones, glucose and other chemical levels in the body can go out of whack so can histamine levels. And brain histamine levels do influence its function.
Hey, HV. can you recommend me a regimen?
The most important nutrient I recommend focusing on is trimethylglycine (TMG), which is a great methyl donor. Recommended dose is 1g three times daily.
Coleus forskohlii, nettle leaf and watercress also great for countering histamine levels. Dosage will depend on the form you get.
Zinc can also reduce histamine levels. Recommended dose is 50mg total daily. If you can find 25mg tablets this would be the best, 25mg twice daily.
I'm doing the methionine + calcium route right now to try to lower the levels based on what I've read online. Opinions on that? I'm gonna try to add in some TMG though because I do remember reading about that stuff.
Methionine is involved in the production of SAMe, a methyl donor. The TMG I mentioned is a stronger methyl donor containing 3 methyl groups as opposed to the one methyl group SAMe provides. As TMG breaks down it forms in to dimethylglycine (DMG) then in to SAMe and finally glycine.
As far as calcium goes, calcium is a histamine regulator both stimulating its release and inhibiting it s release depending on a number of factors. So I would not rely on calcium as a means of keeping histamine down.