Yes, parasites can develope resistance to anything over time if it does not kill them.

My opinion is that this might be possible, but it's irrelevant due to the sheer number of anti-parasitical herbs that nature provides. I have practiced rotating remedies for years and there are still several highly recommended herbs that I have yet to try. In my opinion, a more significant problem is that people fail to cleanse deeply enough to make a lasting difference. They take a few layers of sludge off the surface of their intestines and feel better, so they think they are done. Before long the parasites have recolonized and they are sick again. The ones that come back may or may not come back resistant. It is a good idea to rotate remedies.

With regard to resistance, many years ago I read an article in the newspaper that the bug extermination companies were switching to a different kind of poison because the bugs had become resistant to what they'd been spraying. A few years later, the extermination companies were using the original poison again. I don't know whether they changed the original formula, added something to it, or if the bugs become unresistant from lack of exposure. I suspect it was the latter, but I haven't done any research to find out.

It is always a good idea to rotate formulas to keep them guessing and catch them off guard.

parasites can develop resistance to almost anything, which explains how they survived millions of years. To make sure that doesn't happen, take maximum doses every time, rather then reduced doses. They develop resistance really quickly when fed borderline toxic amounts (toxic to them). Then what you are left with are strains which survived and then when they start multiplying you end up with a lot harder infection to get rid of. Also, resistance means higher virulence almost always, which only makes the whole thing worse.

One other thing to keep in mind: some components of these herbs/drugs may not have sufficient tissue penetration to reach in them low blood flow areas. In that case even if you take proper amount of herbs, you may be helping them develop resistance. This may explain why infections in areas of low blood flow are hard to get rid of, and over time may become impossible to get rid of: arthritis, gum disease, sinus infections and so on.

Iodine (black walnut hull) is one thing they can never develop resistance to, as it "burns" them with oxigen. There is no 'Fire-proof' parasite. But in comparing effects of Atomidine (atomic iodine), with Black-Walnut hull, I concluded that Atomidine was far superior. It is all Iodine (and water), while with Black-Walnut hull there is no telling what's in it, especially how much Iodine there is in it, as that depends on manufacturing practices and Iodine content on the soil the tree grew on.

Yes, any animal that uses millions of eggs as a survival stragety, which most parasites do, will have some offspring that are resistant to whatever you throw at them Luckily, there are so many herbs, you will never run out, and if you have bigger worms, then use digestive enzymes, and get them that way.
(Zymex 2 is a good example, I like bromelain, it agrees with me and does the same thing.)
Julie