A special property of pectins is their ability to bind heavy metals by a complexation mechanism. This is possible because pectins are negatively charged polyelectrolytes and can bind positively charged heavy metal ions. The binding affinity is very high for lead, followed by barium, cadmium and strontium and decreases to earth alkali and alkali ions. With that low methoxyl pectins are an antidote for heavy metal poisoning by an increased excretion in the stool and with that a reduced resorption. But also heavy metals once resorpted are excreted in the urine.

Date:   6/5/2005 2:25:43 PM ( 19 y ago)

Reducing the 137Cs-load in the organism of "Chernobyl" children with apple-pectin.

Nesterenko VB, Nesterenko AV, Babenko VI, Yerkovich TV, Babenko IV.

Belrad Institute of Radiation Safety, Charity House, 11 Staroborisovsky Trakt, 220114 Minsk, Republic of Belarus. nester@hmti.ac.by

As a complement of standard radioprotective measures, apple-pectin preparations are given, especially in the Ukraine, to reduce the 137Cs uptake in the organism of children. The question has been raised: is oral pectin also useful when children receive radiologically clean food, or does this polysaccharide only act in binding 137Cs in the gut, blocking its intestinal absorption? In this case, pectin would be useless if radiologically clean food could be given. The study was a randomised, double blind placebo-controlled trial comparing the efficacy of a dry and milled apple-extract containing 15-16% pectin with a similar placebo-powder, in 64 children originating from the same group of contaminated villages of the Gomel oblast. The average 137Cs load was of about 30 Bq/kg bodyweight (BW). The trial was conducted during the simultaneous one-month stay in the sanatorium Silver Spring. In this clean radiological environment only radiologically "clean" food is given to the children. The average reduction of the 137Cs levels in children receiving oral pectin powder was 62.6%, the reduction with "clean" food and placebo was 13.9%, the difference being statistically significant (p <0.01). The reduction of the 137Cs load is medically relevant, as no child in the placebo group reached values below 20 Bq/kg BW (which is considered by Bandazhevsky as potentially associated with specific pathological tissue damages), with an average value of 25.8 +/- 0.8 Bq/kg. The highest value in the apple-pectin group was 15.4 Bq/kg, the average value being 11.3 +/- 0.6 Bq/kg BW.

Publication Types:
Clinical Trial
Randomized Controlled Trial

PMID: 14745664 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abs...
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Pectins - naturally
Binding and Excretion of heavy metals and their radionuclides

Date: Wed, 29 Mar 2000 12:05:01 -0800
From: "marco saba"
Reply-To: du-list@eGroups.com
http://www.pectin.org/funde/englisch/epress06_2.htm

This mechanism is based on oligogalacturonides degraded from pectin by microorganisms in the colon and with that resorpable into the body. This oligogalacturonides either catalyze an excretion reaction or bind itself heavy metals resulting in an excretion via urine. The way of action is not clearly understood up to now....

From Herbstreith & Fox and Sanofi-Winthrop the product Medetopekt was developed with the assistance of the Russian Institute of Biophysics and some other medicinal centers. Medetopekt is a tablet consisting of a low methoxyl apple pectin with a special improved binding capacity for heavy metals especially for lead and some other pectin rich apple components like liquid pectin dried, apple fiber and apple powder. The effectiveness of Medetopekt was first studied with rats. It could be shown that the excretion of lead, cadmium and strontium was improved by Medetopekt. Consequent human studies in Kiew and Minsk varified these results.

Medetopekt was tested against crude wheat fiber. In the first study the lead content in the blood was measured before and after 21 days of Medetopekt therapy. The results with crude wheat fiber were not significant. Medetopekt reduced the lead concentration from 0,48 mg per liter to 0,37 mg per liter by 23 % (see fig. 3).

The excretion of lead via urine was significantly increased after 21 days. The volunteers left during the study their unfriendly environment. With that the lead intake and naturally occuring excretion was reduced (see fig. 4).

After some time the microorganisms probably adapted to the pectin enriched food and produced more pectin degrading encymes and with that more oligogalacturonides were formed resulting in a higher resorption of these substances and a high excretion of lead via urine at the end of the study. A further longer study carried out in these days will show if the excretion will be further increased over a longer period. In the strontium study the radioactive strontium was measured in the urine. The excretion of strontium was not changed significantly by crude wheat fiber but increased with Medetopekt from 0,060 Curie per liter to 0,115 Curie per liter within 21 days (visit 3, see fig. 5).

INFLUENCE OF THE RADIATION ON THE HEALTH OF THE CHILDREN IN BELARUS 12 YEARS AFTER CHERNOBYL

IMPACT OF RADIATION ON THE HEALTH OF CHILDREN IN BELARUS 12 YEARS AFTER CHERNOBYL
by Vasily B. Nesterenko
corresponding member of the National Academy of Sciences of the Republic of Belarus,
Professor, Doctor of Technical Sciences, Director of the.. http://www.bdg.minsk.by
http://www.bdg.minsk.by/cegi/Chernobyl/1/Nester/NESTER2.html
Medetopekt http://www.e-apteka.ru/medic/preparats/sanofi_pr/medetopect.asp

A New Approach to Metastatic Cancer Prevention: Modified Citrus Pectin (MCP), A Unique Pectin that Blocks Cell Surface Lectins http://www.thorne.com/altmedrev/mcp.html by Parris M. Kidd, PhD

ABSTRACT

Citrus pectin (CP) is a commercially available, water-soluble fiber with proven health benefits. The branching polysaccharide structure of CP can be altered to produce a lower molecular weight, galactose-rich, modified citrus pectin (MCP) which has unique properties. Specifically, MCP, but not CP, might help retard cancer metastasis by combining with an array of galactose-specific proteins on the cancer cell surface called galectins (for galactose-specific lectins). As with many human cancer cell lines that have been studied, the potentially metastatic B16-F1 (mouse melanoma) and MLL (rat prostate) cells carry galectins, cell surface proteins that bind to galactose on neighboring cancer cells and oligosaccharides on the host cell surface. MCP inhibits metastasis by the cells in the mouse and the rat, respectively. Unlike the much larger CP polysaccharide, galactose-rich MCP may be small enough to access and bind tightly with galectins on the cancer cell surface, saturating the galactose binding sites of the cancer cell lectins, and thereby inhibiting both aggregation of tumor cells and adhesion to normal cells. Thus deprived of adhesion, the cancer cells fail to metastasize. Undeniably, important gaps still exist in the current understanding of MCP's clinical efficacy and its mode(s) of action. But MCP's apparent safety and proven anti-metastatic action, and the lack of proven therapies against metastasis, together may justify its inclusion into comprehensive orthomolecular anticancer regimens. (Alt Med Rev 1996;1:4-10.)

http://nucnews.net/nucnews/2000nn/0003nn/000329nn.htm
http://www.ippnw.ch/content/pdf/Sympo_15022003/smw_2004_01_10223%20nesterenko...

http://64.233.187.104/search?q=cache:7NDtycPILD4J:www.serve.com/nukeresister/nr136.pdf+apple+pectin+depleted+uranium&hl=en
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abs...

 

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