Prototype article for the theory that all diabetes cases stem from a heavy vitamin D deficiency, with a suggested course of treatment and recovery.

Date:   1/4/2011 8:00:29 PM ( 13 y ago)

Excited over connections between D3 and Diabetes Mellititus

I’ve been looking more and more into the role of D3 (cholecalciferol) in the functions of the pancreas, intestinal tract and whatever else I can find. Namely my aim has been to collect all the material I could over why treating Diabetes Mellititus as a vitamin deficiency makes sense, and the evidence for D3′s role in the endocrine/metabolic system.

I find it very important news that endocrinologists need to have access to for trials and testing. The original news clipping is from 2008, and I can hardly believe that D3 hasn’t been much, much more actively a part of diabetes research!

On the vitamin D council site under Research > Diabetes, it says:

“Vitamin D helps maintain adequate insulin levels. Preliminary evidence suggests supplementation can increase insulin levels in people with type 2 diabetes. Prolonged supplementation may help reduce blood sugar levels.”

Current medical knowledge is unclear as to the ideal D3 blood levels, as earlier research on D2 has shown high levels of D2 (ergocalciferol) to be toxic, and confusion between the two reigns in almost all medical circles.

D3 levels however are logically low in Western society at large, as the average child, teen and adult are inside most of the time at work, school and home, with much time dedicated to television and computers. Solar exposure is minimum, and full-body solar exposure near unheard of except in western european circles where nude bathing is acceptable.

Complicating the deficiency of D3 is diet, of which has been in western cultures, simple carbohydrates with minimal protein and plant material. Between 50-80% of calories consumed come from the grains family, as per the FDA recommendations since 1910 based upon study of an agricultural population. The familiar Food guide pyramid places bread as the founding stone of our diet, the most common being white breads from bleached white flour. Dependency upon simple carbohydrates and monosaturated fats in the Western diet complicates vitamin deficiencies. The worst depleter of essential nutrients in the body is sugar, in it’s various forms, highfructose corn syrup, cane sugar, and it’s other various forms. (More documentation desired in reguards to the role of processed foods complicating the efficient use of D3 in the body.)

“A diet rich in sugars will catch our pancreas and adrenal glands in a biochemical see-saw, overworking them. It could weaken pancreas and result in diabetes. Cardiovascular complications that follow excess glucose or fats kill many diabetics. If our body is unable to use all of the extra fats and cholesterol produced from sugars,it must dump the additional load. Fats can be deposited in the cells of our liver, heart, arteries, fat tissues, kidneys, muscles, and other organs. That is beginning of fatty degeneration.” Curezone.org, Sugar, Diabetes, and other Incurable Diseases

Simple carbohydrates contribute to the depletion of all essential vitamins in the body:

“Sugars increase our body’s production of adrenaline by four times, which puts the body into a state of ‘fight or flight’ stress, without anything to fight or flee from , except the consumption of sugar. This stress reaction increases the production of both cholesterol and cortisone. Cortisone inhibits immune function.

Sugars lack the vitamins and minerals required for their own metabolism. To be metabolized, sugars must draw on our body’s stores of these nutrients. The more sugars you eat, the more vitamins and minerals you need. It can leach B, C, D vitamins, and those minerals:

calcium, phosphorous, iron, selenium, zinc, chromium, vanadium, tin, boron, bismuth, rear earth elements etc. from our teeth, bones, and tissues. As these are depleted, our body becomes less able to carry out other functions that require minerals and vitamins to be present: to metabolize fats and cholesterol; to convert cholesterol into bile acids for removal from our body through the stool; or to burn-off excess fats as heat or increased activity. As a result , our cholesterol level rises; our metabolic rate goes down; fats burn more slowly; gall stones are crystallizing in or liver; we feel less like exercising, and our weight is increasing. We have already started walking our way to cancer, diabetes and cardiovascular diseases.” Curezone.org, Sugar, Diabetes, and other Incurable Diseases

A lack of high quality protien in one’s diet contributes to the development of diabetes mellititus in the state of vitamin D3 deficiency.

Pancreatic nerve damage occurs in the onset of Diabetes Mellititus. Under conditions of prolonged stress, the brain and liver signals the pancreas to decrease the production of insulin. The pancreatic nerve relating to beta cells (insulin producing cells) withers in reaction to reduced activity (as nerve pathways grow weak when underused), and in the absence of proper levels of IGF 1 cannot regenerate.

D3 plays an essential role in the maintenance both of the pancreas and the immune system, as well as every organ in the body. D3 protects pancreatic Beta cells from attack, and in a severe deficiency of D3, the immune system malfunctions, resulting in the starvation of beta cells.

IGF1 is the essential hormone for new cell growth, in particular nerve cells. A high- quality protein intake is essential to the production of IGF 1, specifically for nerve cells for the regeneration of the pancreatic nerve cells addressing the islet of langerhans.

“IGF-1 is a primary mediator of the effects of growth hormone (GH). Growth hormone is made in the anterior pituitary gland, is released into the blood stream, and then stimulates the liver to produce IGF-1. IGF-1 then stimulates systemic body growth, and has growth-promoting effects on almost every cell in the body, especially skeletal muscle, cartilage, bone, liver, kidney, nerves, skin, hematopoietic cell, and lungs. In addition to the insulin-like effects, IGF-1 can also regulate cell growth and development, especially in nerve cells, as well as cellular DNA synthesis.” Wikipedia, IGF1

The best sources of protien are, in decending order, insects, fish, fowl (poultry), wild game, and lastly, cattle. Cattle are unlikely candidates for quality protein, as most are not raised on grass and have much higher concentrations of monounsaturated fats than polyunsaturated fats.

However a high intake of polyunsaturated fats negates the concerns of consuming monounsaturated fats as they regulate LDL levels in the blood. Polyunsaturated fats are available in high levels in olive oil sold in dark bottles, alge-based food supplements, fish oil capsules, fish, wild game, eggs (other sources may be added later). Polyunsaturated fats are also known as Omega 3, Omega 6, and Omega 9. The ideal ratio of LDL cholesterol to HDL cholesterol is 1:1.

In the absence of the essential factors required for beta cell regrowth and nerve regrowth, scar tissue forms on the pancreatic nerve linked specifically to the Islet of Langerhans.

Study of diabetic white mice proves promising for diabetes type 1

(Help is needed to hunt down this article.) A study in 2002-2003 revealed scar tissue on the nerves surrounding the islet of langerhans on the pancreas. Bombarding the scarred nerves with capciasinresulted in regrowth of new nerve tissue, resulting in normal insulin production and self-regulation of glucose for up to 6 weeks.

Current doses of D3 recommended by FDA much too low for theraputic effect

“Studies show that if you go out in the summer sun in your bathing suit until your skin just begins to turn pink, you make between 10,000 and 50,000 units of cholecalciferol in your skin. Professor Michael Holick of Boston University School of Medicine has studied this extensively and believes a reasonable average of all the studies is 20,000 units. That means a few minutes in the summer sun produces 100 times more vitamin D than the government says you need! As discussed in other pages, this is the single most important fact about vitamin D.” Vitamin D Council

Current FDA recommendations are 400-1000 ie a day of D3, much too low to have theraputic effect in the body as evidenced by the body’s own production of D3 in sunlight.

D3 is toxic at extremes
“In 1999, Vieth indirectly asked the medical community to produce any evidence 10,000 units of vitamin D a day was toxic, saying “Throughout my preparation of this review, I was amazed at the lack of evidence supporting statements about the toxicity of moderate doses of vitamin D.” He added: “If there is published evidence of toxicity in adults from an intake of 250 ug (10,000 IU) per day, and that is verified by the 25(OH)D concentration, I have yet to find it.” Like most medication, cholecalciferol is certainly toxic in excess, and, like Coumadin, is used as a rodent poison for this purpose. Animal data indicates signs of toxicity can occur with ingestion of 0.5 mg/kg (20,000 IU/kg ), while the oral LD50 (the dose it takes to kill half the animals) for cholecalciferol in dogs is about 88 mg/kg, or 3,520,000 IU/kg. This would be equivalent to a 110-pound adult taking 176,000,000 IU or 440,000 of the 400 unit cholecalciferol capsules.Vieth reports human toxicity probably begins to occur after chronic daily consumption of approximately 40,000 IU/day (100 of the 400 IU capsules). Heavy sun exposure when combined with excessive supplement use is a theoretical risk for vitamin D toxicity, but if such a case has been reported, I am not aware of it. ” Vitamin D council

D3 and Calcium supplements give hypercalcemia

D3 is the major factor in the intestines for the absorption of calcium. At proper doses all calcium necessary for proper function and bone health will be acquired through food intake.

Current supplements of calcium provide megadoses, which in the presence of D3 supplementation will produce in order of progression of symptoms, headache/ migraine, nausea, diarrhea, and at 100 times the FDA reccomendations, kidney stones and permanent kidney damage. In pregnant women, a high blood level of calcium can give heart malformations to the fetus.

Magnesium is essential in use of D3 by the body

“Two interesting cases of Mg dependent Vitamin D-resistant rickets appeared in the Lancet in 1974. Two children, one age two and the other age five, presented with classic rickets. 600,000 IU of Vitamin D daily for ten days did not result in any improvement in six weeks—in either x-rays or alkaline phosphatase—and the doctors diagnosed Vitamin D-resistant rickets. Almost by accident, serum Mg levels were then obtained, which were low in both children. After the treatment with Mg, the rickets rapidly resolved. What does that mean? How can one treat rickets with Mg? Remember, these children took a total of 6 million units, that’s a total of 6,000,000 IU of vitamin D over ten days (it was given as injections so we know the children actually took it). Thus, they had plenty of vitamin D but, in their cases, the vitamin D needed Mg to work.”

Magnesium can be acquired in adequate amounts in sunflower seeds and pumpkin seeds, a handful a day of the seeds mixed with dried berries or grapes with a little salt is ideal. All forms of nuts add an excellent B-vitamin complex supplement to one’s diet, but it is reccomended you make your own trail mix at home to avoid oversalted food products.

Vanadium and Chromium also essential in glucose regulation

Vanadium and Chromium also assists in the regulation of glucose levels in the blood. Tomatoes, romaine lettuce, whole grain breads (containing the wheat germ and whole grain, not available in US standard grocery stores), and lean meats as

those listed above for polyunsaturated fats. Black pepper, shellfish, mushrooms, dill seed, parsley, soy, corn, olives, olive oil, and gelatin all contain vanadium.

Absorbtion of all essential nutrients besides D3 is best obtained through a treatment-focused and goal-focused diet

Most of the benefits of multivitamin tablets are lost in the digestive tract, as they are not delivered in an optimally digestible fashion. Plants, protiens and fats preserve the vitamins (protohormones) best through the bile of the stomach, resulting in proper absorbtion through the digestive track in a reliable fashion.

Suggested method of treatment
Up to 85% of type 1 diabetics still have beta cell function

Type 1 diabetes is split up into two branches, type 1a which is autoimmune, 10%-20%, and type 1b 80%-90%, which still retain some beta-cell function. Blood tests can determine if the body is still producing insulin, c-peptide is the measurement taken to determine the level of insulin production in the body.

Process of curing type 1 diabetes THEORETICAL at this time (January 2010).

Optimal immune system function must first be achieved by effective doses of D3 by oral, intravenous or intramuscular form, and monitored by an endocrinologist via 25 (OH)D3 (D3 blood tests) at regular intervals, ideally at 2-4 week time periods with interviews with the patient.

The patient must be dedicated to a high protein intake and a severe reduction of bleached flour and sugar-based carbohydrates, to avoid the requirement of heavy extra insulin doses and stressing of the bodily systems by the depletion of nutrients absorbed by the diet.

Optimal diet would consist of 40% polyunsaturated fats, 30% protien, and 30% carbohydrate in the form of nuts and fruit. This diet model places meats as the most important group along with fats as a slow-digesting source of energy through the day. Alongside the breakdown of protiens, dietary fiber in the form of raw fruits, vegetables and nuts, and carbohydrates in the form of cracked-kernel bread, this is the best method to keep blood glucose levels stable and regular, which is ideal for avoiding stressing a recovering endocrine system.

The importance of eggs cannot be understated. They are delicious, high-protien, and easily accquired. Insects would be the ideal high-level source of protien, as they are 90% or more protien, but they are not sold as food in western cultures, with the exception of mealworms and crickets as petfood.

The optimum goal is to adhere to a solid diet to regain the immune and regenerative processes of the body by:

1. Sufficiently supplement with D3 until healing processes have returned to normal

2. Up quality of diet and intake of protien and polyunsaturated fats to maximize regeneration

3. Up quality of diet through raw and cooked vegetables and fruits instead of multivitamins

4. Monitor levels of c-peptide in the blood to watch for flags of beta cell regeneration

5. Lower supplementation of subcutaneous insulin slowly to match the body’s c- peptide levels and test results accordingly

6. Maintain D3 supplementation orally at minimum doses to prevent relapse

7. Continuously monitor fasting bloodsugars (morning/dawn sugars) for signs of reoccurrence

Expected treatment time depends upon the length of the period of time the patient has spent on insulin. The immune system and the body’s regenerative abilities will take time to recover, but high beginning doses with subsequent oral supplementation of D3 should result in dramatic reversal of diabetic complications, with the speed of healing of small cuts as a reliable indicator.

It is possible that the supplementation of D3 will not result in the recovery of beta cells in the pancreas if basal insulin dosages are not lowered, as the body may identify the subcutaneous injected insulin as it’s own and not produce natural insulin. C- peptide level tests are necessary to monitor the performance of the islet of langerhans, and can be performed alongside quarterly HbA1C blood tests.

Insulin pump treatment on Novorapid is ideal, as the patient is free to dose as needed or lower temporary and daily basal insulin as needed on a protien-heavy diet. Basal insulin should take over for meal boluses as a diet heavy in fiber, protien and fats will result in a very slow release of glucose to the blood. The patient will be vulnerable to hypoglycemia (low blood sugar) on high doses of insulin for quick- acting carbohydrates, as high glycemic-index foods do not match the acting duration of the insulin. Quick acting-carbohydrates will still be vital to the recovery from low blood sugars, with grape sugar as the fastest-acting aid, but avoidance of simple carbohydrates is highly recommended.

A homemade trailmix of sunflower seeds and pumpkin seeds, mixed with dried berries or grapes and whole, unsalted nuts is the ideal snack for dealing with lows while in recovery. It covers a whole range of nutritional needs, is cheap, and can be easily carried around in a baggie. No more than a handful a day! Make the ratio about 1 part raisins/dried berries, 1 part seeds, and 1/2 part nuts. Unsalted ingredients are best, but salt levels shouldn’t be a heavy worry, as proper D3 blood levels also cover hypertension issues (high blood pressure).

“Hypertension : Clinical and experimental data support the view that vitamin D metabolism is involved in blood pressure regulation and other metabolic processes.” Vitamin D Council, Research page

Expected minimum treatment time is 1-2 years. Optimal treatment dosages of D3 are currently estimated at 50,000 iu/1,250 mcg of D3, the equivalent of five hours under UVb solar rays, at regular intervals, possibly once a week for three months administered by the patient’s endocrinologist, with supplementation at home of 5,000 ie/125 mcg to 10,000 ie/250 mcg daily. Close monitoring is essential, alongside documentation and positive coaching and/or group therapy to maintain the patient’s motivation.

Daily supplementation after three months should be maintained between 5,000 ie/ 125mcg to 10,000 ie/mcg to maintain 25(OH)D3 blood levels at peak performance throughout the year, as the amount of solar exposure a patient receives daily will always fluctuate.

On Vitamin D Council’s front page, the suggested target levels of D3 in the blood are 50–80 ng/mL (or 125–200 nM/L).

Ayurvedic supplement ‘Dyboss’ may aid in relieving or curing Diabetes Type 1
Personally I am of the opinion that D3 is far more important in the care of Diabetes type 1 and 2, and that these herbal supplements may simply contribute overall to diabetic health through the vitamin complexes present in the herbs. Of note Gymnema Sylvestris, which I suspect might contain some D3, and terocarpus Marsupium, which is reported to stimulate Beta cell growth in the pancreas.

Diabetes Mellititus Information is an Indian information site on Diabetes, both type 1 and 2. Indian doctors use western medical practices of documentation, clinical trials and research, thanks to the long-lived colonial association between India and England, and the continued heavy trade of goods such as fine cotton and denim. Information about the treatment of Diabetes in India however is not widely spread in western countries, except for internet rumours of so-called ‘herbal’ cures.

However with new knowledge of the importance of Vitamin D3 (cholecalciferol) in human metabolisim of glucose and the synthesis of pancreatic beta cells, a proven herbal supplement may signifigantly aid the treatment and recovery from diabetes mellititus.

A similar product with a separate dosage level of the varying herbs exists for diabetes type 2 (adult onset diabetes) called Diabeta.

All information below is from the dyboss information page.

Pricing for Dyboss is at high, if manageable prices. A 2-3 month supply is 45 US dollars, a 7-10 month supply is 120 US dollars. Dyboss does NOT appear to remove the requirement of insulin supplementation, as the role of the deficiency of D3 in Diabetes has not been addressed in India yet.

Before you buy any herbal supplements, I will underline the fact that supplementation with D3 is cheap, available at your local grocery, healthfood store and pharmacy, and is prescription-free. Your recovery will not be immediate, but improvements are easily felt from day to day.

All diabetic complications are signs of D3 deficiency
Periodontal (tooth) rot from within is often the first sign of deficiency, followed by increased appetite for simple carbohydrates and fats. Slowed healing processes and sleep deficiency is next, resulting in mental distress and fatigue for the patient. D3 is essential in healing processes, as it is a vital product of the skin which the body cannot heal itself without. D3 is noted for it’s role in improving skin condition, but never has it been linked before to either diabetes type 1 or 2. It’s role in promoting the production and use of IGF1 in the body has not yet hitherto been researched in depth (to my knowledge).

Reliability of VitaminDCouncil.org
The Vitamin D Council is a web page and organization of PhD doctors committed to gathering the different studies relevant to the role of D3 in the body to result in a complete index of the latest research upon this essential protohormone, D3 (cholecalciferol). Within it’s research page is listed all the different studies grouped by the relevant condition/disease the independant research groups/doctors have been studying. Reading several of the research papers is essential to counting the data as reliable and sound. Carrying this information to endocrinologists is essential to revolutionalizing the treatment of all types of diabetes.


 

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