Lethal levels of propofol in his system. He just wanted to go to sleep.

Date:   8/24/2009 9:06:35 PM ( 15 y ago)

Coroner rules Jackson’s death a homicide

Court document reveals singer had lethal levels of propofol in system

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Jackson's death ruled homicide   Aug. 24: A Los Angeles County coroner rules Michael Jackson's death a homicide. NBC's Jay Gray reports. NBC News Channel

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Coroner: Jackson’s death a homicide   Aug. 24: The Los Angeles coroner rules Michael Jackson’s death a homicide. Msnbc.com’s Courtney Hazlett reports.

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LOS ANGELES - The Los Angeles County coroner has ruled Michael Jackson’s death a homicide, a law enforcement official told The Associated Press, a finding that makes it more likely criminal charges will be filed against the doctor who was with the pop star when he died on June 25.

A designation of homicide means that Jackson died at the hands of another, but does not necessarily mean a crime was committed.

Forensic tests found the powerful anesthetic propofol acted together with at least two sedatives to cause Jackson’s death June 25 in his rented Los Angeles mansion, according to the official, who spoke on condition of anonymity because the findings have not been publicly released.

Dr. Conrad Murray, a Las Vegas cardiologist who became Jackson’s personal physician weeks before his death, is the target of a manslaughter investigation by the Los Angeles Police Department. Dateline NBC's Josh Mankiewicz confirmed that Murray is the target of a manslaughter probe.

A search warrant affidavit unsealed Monday in Houston includes a detailed account of what Murray told investigators.

According to the document, Murray said he’d been treating Jackson for insomnia for about six weeks with 50 milligrams of propofol every night via an intravenous drip. But he said he feared Jackson was forming an addiction to the anesthetic, which is normally used in hospitals only, and was attempting to wean his patient by lowering the dose to 25 milligrams and adding the sedatives lorazepam and midazolam.

Singer called propofol his ‘milk’
That combination succeeded in helping Jackson sleep two days prior to his death, so the next day, Murray told detectives he cut off the propofol — and Jackson fell asleep with just the two sedatives.

Then around 1:30 a.m. on June 25, starting with a 10-milligram tab of Valium, Murray said he tried a series of drugs instead of propofol to make Jackson sleep. The injections included two milligrams of lorazepam around 2 a.m., two milligrams of midazolam around 3 a.m., and repeats of each at 5 a.m. and 7:30 a.m. respectively.

But they didn’t work.

getCSS("3053751") Slideshow   Michael Jackson: 1958 - 2009 Click to see pictures from the highs and lows of Michael Jackson's career.

Murray told detectives that around 10:40 a.m. he gave in to Jackson’s “repeated demands/requests” for propofol, which the singer referred to as his “milk.” He administered 25 milligrams of the white-colored liquid, — a relatively small dose — and finally, Jackson fell asleep.

Murray remained with the sedated Jackson for about 10 minutes, then left for the bathroom. No more than two minutes later, he returned — and found Jackson had stopped breathing.

“There’s no surprise there” that death could result from such a combination, said Dr. David Zvara, anesthesia chairman at the University of North Carolina at Chapel Hill.

“All those drugs act in synergy with each other,” Zvara said. Adding propofol on top of all the other sedatives “tipped the balance.”

Singer had bed sores
Besides the propofol and two sedatives, the coroner’s toxicology report found other substances in Jackson’s system but they were not believed to have been a factor in the singer’s death, the official told the AP.

When he died, Jackson was skinny but not overly emaciated, and his body had bed sores, the official said. The singer is believed to have developed bed sores in the months following his 2005 acquittal of child molestation charges, when he went into seclusion and spent long stretches in bed.

AFP - Getty Images According to the search warrant, Dr. Conrad Murray, Michael Jackson's personal physician, told LAPD detectives that he had been treating Jackson for insomnia for about six weeks.

Murray has spoken to police and last week released a video saying he “told the truth and I have faith the truth will prevail.” Murray did not say anything about the drugs he gave to Jackson. Murray’s attorney, Edward Chernoff, had no immediate comment but has previously said Murray never administered anything that “should have” killed Jackson.

A call to the coroner’s office was not returned Monday.

Jackson’s family released a statement Monday, saying it has “full confidence” in the legal process and the efforts of investigators. It concludes: “The family looks forward to the day that justice can be served.”

The 25 milligrams of propofol Murray told police he gave Jackson the day he died “is not a whopping amount,” said Lee Cantrell, director of the San Diego division of the California Poison Control System. But by combining propofol with a cocktail of the other sedatives, known as benzodiazepines, it “may have been the trigger that pushed him over the edge,” Cantrell said.

Cantrell said it’s perplexing that someone would give various benzodiazepines if one was found not to be effective.

“This is horrible polypharmacy,” he said, referring to the interaction between the various drugs. “No one will treat an insomniac like this.”

The affidavit says Murray told investigators he didn’t order or buy any propofol and had found about eight bottles of it in Jackson’s home along with numerous other medications. But investigators served a search warrant Aug. 11 at a Las Vegas pharmacy and uncovered evidence showing Murray legally purchased from the store the propofol he gave Jackson the day he died.

Murray didn’t tell paramedics or doctors at UCLA hospital where Jackson was rushed June 25 about any drugs he administered other than lorazepam and flumazenil, according to the affidavit. The document says it was only during a subsequent interview with Los Angeles Police detectives that Murray gave a more full accounting of the events leading up to the 911 call.

The coroner’s office has not publicly released its autopsy findings, citing a request from police detectives to withhold results until their investigation is complete.

Homicide, or “death at the hands of another,” is one of several possible findings in a coroner’s death investigation. The designation does not necessarily mean a crime was committed though it is a useful starting point for prosecutors, said Dr. Michael Baden, the former chief medical examiner in New York City and a forensics expert involved in many high-profile murder cases.

“It is an easier prosecution when the medical examiner calls it a homicide,” said Baden, who is not involved in the Jackson investigation.

getCSS("3053751")   Drugs on Jackson’s final night Michael Jackson was given a series of sedatives by Dr. Conrad Murray on June 25, the day the singer died, according to an affidavit released Monday in Houston. 1:30 a.m. — 10 milligram tablet of Valium, a sedative. 2 a.m. — 2 milligrams of the sedative lorazepam (brand name Ativan) given intravenously. 3 a.m. — 2 milligrams of the sedative midazolam (brand name Versed) given intravenously. 5 a.m. — 2 milligrams of lorazepam given intravenously. 7:30 a.m. — 2 milligrams of midazolam given intravenously. 10:40 a.m. — 25 milligrams of propofol (brand name Diprivan) given intravenously and diluted with lidocaine (brand name Xylocaine). 10:50 a.m. — Doctor leaves Jackson’s room; returns minutes later to find Jackson not breathing. Begins CPR and gives 0.2 milligrams of flumazenil (brand name Anexate), used to reverse sedatives.

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