I don't know anything about Cute Site Builder, but I run VPC on my PowerBook G4 and it works like a charm!

My company uses Windows XP and some pretty lousy propietary PC based software and everything runs beautifully. It gives me the best of both worlds because it really is like having two computers in one, and I can switch back and forth without having to shut down my computer and re-open with the other system. The new Macs with the intel chip have something called Bootcamp which will allow you to run PC programs too, but you can't switch back and forth like I can...you open in one system and stay in that system until you shut your computer down.

I understand that Virtual PC for Mac has come a long way and doesn't pose the problems that the older versions used to. My understanding is that, once loaded, you can run any kind of PC software on it. I would think that your Cute Site Builder would run fine, but you might want to contact the manufacturer and see what they say.