Mayo Clinic just published a study showing that particles comprised of calcium phosphate trigger atheroscleroris. This link, long speculated, gives more importance to the treatment of soft tissue calcification.

Date:   5/17/2007 1:09:26 PM ( 17 y ago)

New Study from Mayo Clinic Shows That Calcifying Particles May Trigger Atherosclerosis

For decades, soft tissue calcification (STC) has been recognized as a passive, after-the-fact process resulting from injury or old age; however with the advent of new technologies, many medical professionals are now realizing that STC may be the cause, instead of the effect, of many of our most common illnesses.
Scientific evidence is increasingly linking tiny nano-sized calcifying particles to the initiation of atherosclerosis. One of the first tests to prove this point is a scientific test called Koch’s postulate. This where a pathogen or suspected causal agent to a certain disease is taken from one animal and then injected into a second healthy animal to see if the animal develops the same disease.

Last week, researchers from the Mayo Clinic presented results at the 2007 Experimental Biology meeting in Washington, D.C that may change the way science views calcification.

The study's author, Maria Kraemer, a Mayo Graduate School student in Rochester, Minn., and colleagues isolated and propagated self-replicating, calcifying nanoparticles from human arteriosclerotic aneurysms and kidney stones and then inoculated animal models with the calcified nanoparticles. A second group of models received a diluted inoculation. Blocked arteries were apparent in some animals in both groups 35 days after receiving the dosage and showed the presence of nanoparticles near the plaque-filled arteries. The study suggests that nanoparticles potentially represent a previously unrecognized factor in the development of arteriosclerosis and calcific arterial disease.

Over the past few years, researchers have used various names to characterize these nano-sized particles that are composed primarily of calcium and phosphorous. They have been called nanobacteria, basic calcium phosphate crystals (BCP’s) and most recently, calcifying nano-particles (CNPs). Regardless of the name, the data is mounting that calcium phosphate crystals may be more than a passive and secondary condition. Considering that they are associated with more than half of all chronic disease affecting the population, more research on these particles is desperately needed.


 

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