Glutathione Kill Mycobacteria!

Date:   2/7/2009 9:52:55 PM ( 15 y ago)

This is good news. mycobacteria infections are some of the most difficult to deal with. pneumonia and tuberculosis are two common myco infections, there are many others. But glutathione (GSH) does not kill the mycobacteria direclty, rather GSH raises levels of your body's natural killer cells, and the NK cells then kill the mycobacteria.

http://www.ncbi.nlm.nih.gov/pubmed/18338948


Natural killer cells, glutathione, cytokines, and innate immunity against Mycobacterium tuberculosis.
Millman AC, Salman M, Dayaram YK, Connell ND, Venketaraman V.

Division of Infectious Diseases, UMDNJ-New Jersey Medical School, Newark, NJ 07103, USA.

It is becoming increasingly apparent that natural killer (NK) cells play a crucial role in innate defense mechanisms against Mycobacterium tuberculosis infection. Furthermore, NK cell functions are dependent on adequate levels of glutathione. In this study, we examined whether the NK cell-mediated growth control of intracellular M. tuberculosis is dependent on adequate levels of glutathione. We investigated the effects of glutathione both alone and in combination with interleukin-2 (IL-2) or IL-12 or both in modulating NK cell functions, such as cytolytic activity, activating receptor expression, induction of apoptosis, and cytokine synthesis. Our results strongly indicate that glutathione in combination with IL-2+IL-12 augments NK cell functions, leading to control M. tuberculosis infection.

 

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