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Re: EDTA more about its antifungal activity

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  • EDTA more about its antifungal activity   dvjorge   15mo
    • Great article! Thanks for the link. ... ... The problem is...   fectoid2   15mo
      • Nonprescription EDTA widely available   North   15mo
      • Re: EDTA more about its antifungal activity   dvjorge   15mo
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        Re: EDTA more about its antifungal activity
        PM dvjorge
        Date: 1/4/2013 2:56:08 PM   ( 15mo ago )
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        The effect of ethylenediamine-tetraacetic acid on Candida albicans.

        AuthorsSen BH, et al. Show all Journal
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000 Nov;90(5):651-5.

        Department of Restorative Dentistry and Endodontology, Ege University, Izmir, Turkey.

        OBJECTIVES: The aim of this study was to evaluate the antifungal effect of ethylenediamine-tetraacetic acid (EDTA) on Candida albicans, comparing it with that of various disinfectants and common antifungal agents.

        STUDY DESIGN: Two clinical oral isolates and 1 standard strain of C albicans were included in this study. Main contents of the test solutions were sodium hypochlorite, EDTA, chlorhexidine, hexetidine, benzalkonium chloride, povidone-iodine, nystatin, and ketoconazole. The agar diffusion method was used to determine the antifungal effects of the solutions. Zones of inhibition were recorded and the results were analyzed statistically by using a 2-way analysis of variance.

        RESULTS: EDTA demonstrated the highest antifungal activity in comparison with routine antifungal drugs and all other solutions (P <.0001). Oral cavity isolate was more resistant to the test solutions (P <.0001).

        CONCLUSION: The selection of irrigating and disinfecting solution in root canals of patients with a particularly high incidence of oral candidiasis gains extreme importance. EDTA may be strongly recommended during endodontic therapy of these patients.
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