I've done a couple of coffee enemas once a week for 3 weeks (so far). I actually get more of this stuff out if I take some psyllium seeds but I feel the enema might be good too. Maybe this thingy is absorbing better from the psyllium seeds.

Very interesting that you say methylation! I'm actually on methylation supplements [MeCbl, AdoCbl, MethylFolate and L-carnitine fumarate] + cofactors. So maybe this is why shit is coming out. Been on it for a month and while I have several side effects, I have major improvements as well. Its supposed to get better with time, but you have to play around a bit with the ratios and stuff. Have not heard about Nitric oxide though?

Anyways, would be really nice if I could point to what kind of stuff this really is, I guess it really got to be parasites/candida or some kind of accumulated fat (maybe not very likely)