Again I am not a doctor, but I have been working with Dr. Lam who has given me some good help in overcoming my adrenal fatigue. I can't help with thyroid problems (I'm sorry I don't have thyroid issues) I just have read in places that treating the thyroid with adrenal fatigue puts an extra burden on the adrenals. Another doctor may be able to help you better with these issues, or you can even ask Dr. Lam, who you can email with your questions or talk to for free (once) (www.drlam.com). As for my experience, I was on glandulars for a while which although they gave me extra energy they were probably causing more problems than they were solving. I don't think they are the best method for the long run (I only started having serious problems with sleeping and hypoglycemia when I started using glandulars). I think the pantothenic acid is definitely necessary, I take 1500 mg a day, and in addition pantethine 900 mg a day (I get this at whole foods). I think it is important to take both at the same time as in my experience they seem to work better together. I have also been using a vitamin C from this online site (the supplement clinic) called Quantum C which I believe is much more efficient than ascorbic acid (it contains several sources of vitamin C, including a fat soluble source, and other ingredients which are said to potentiate vitamin C in the body and make it more useful). To help stay asleep at night I usually have a few spoons of peanut butter, Dr. Lam recommends soaking nuts to release their enzymes and make them more digestible and eating a handful before bed to keep blood Sugar stable throughout the night. Regardless, getting better is not an overnight process, it has taken me a long time to get to where I am now and as I am a Type A personality like I'm sure all of us are I often pushed myself too hard. I hate to say this but it is important to be patient too. Hope some of this can help.